Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention

Manouchehr S. Vafaee, Albert Gjedde, Nasrin Imamirad, Kim Vang, Mallar M. Chakravarty, Jason P. Lerch, Paul Cumming

Research output: Contribution to journalArticle

Abstract

Acute nicotine administration stimulates [14 C]deoxyglucose trapping in thalamus and other regions of rat brain, but acute effects of nicotine and smoking on energy metabolism have rarely been investigated in human brain by positron emission tomography (PET). We obtained quantitative PET measurements of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO 2) in 12 smokers who had refrained from smoking overnight, and in a historical group of nonsmokers, testing the prediction that overnight abstinence results in widespread, coupled reductions of CBF and CMRO 2. At the end of the abstention period, global grey-matter CBF and CMRO 2 were both reduced by 17% relative to nonsmokers. At 15 minutes after renewed smoking, global CBF had increased insignificantly, while global CMRO 2 had increased by 11%. Regional analysis showed that CMRO 2 had increased in the left putamen and thalamus, and in right posterior cortical regions at this time. At 60 and 105 minutes after smoking resumption, CBF had increased by 8% and CMRO 2 had increased by 11-12%. Thus, we find substantial and global impairment of CBF/CMRO 2 in abstaining smokers, and acute restoration by resumption of smoking. The reduced CBF and CMRO 2 during acute abstention may mediate the cognitive changes described in chronic smokers.

Original languageEnglish (US)
Pages (from-to)699-705
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
DOIs
StatePublished - Mar 31 2015
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Oxygen Consumption
Smoking
Thalamus
Nicotine
Positron-Emission Tomography
Putamen
Deoxyglucose
Brain
Energy Metabolism
Oxygen

Keywords

  • metabolism
  • nicotine
  • oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Vafaee, M. S., Gjedde, A., Imamirad, N., Vang, K., Chakravarty, M. M., Lerch, J. P., & Cumming, P. (2015). Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention. Journal of Cerebral Blood Flow and Metabolism, 35, 699-705. https://doi.org/10.1038/jcbfm.2014.246

Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention. / Vafaee, Manouchehr S.; Gjedde, Albert; Imamirad, Nasrin; Vang, Kim; Chakravarty, Mallar M.; Lerch, Jason P.; Cumming, Paul.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, 31.03.2015, p. 699-705.

Research output: Contribution to journalArticle

Vafaee, MS, Gjedde, A, Imamirad, N, Vang, K, Chakravarty, MM, Lerch, JP & Cumming, P 2015, 'Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention', Journal of Cerebral Blood Flow and Metabolism, vol. 35, pp. 699-705. https://doi.org/10.1038/jcbfm.2014.246
Vafaee, Manouchehr S. ; Gjedde, Albert ; Imamirad, Nasrin ; Vang, Kim ; Chakravarty, Mallar M. ; Lerch, Jason P. ; Cumming, Paul. / Smoking normalizes cerebral blood flow and oxygen consumption after 12-hour abstention. In: Journal of Cerebral Blood Flow and Metabolism. 2015 ; Vol. 35. pp. 699-705.
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