Smoking in tuberculosis patients increases the risk of infection in their contacts

Pere Godoy; J. A. Caylà; G. Carmona; N. Camps; J. Álvarez; M. Alsedà; S. Minguell; A. Rodés; N. Altet; J. M. Pina; I. Barrabeig; À Orcau; I. Parron; J. March; N. Follia; M. Sabater; À Domínguez

doi:10.5588/ijtld.12.0696

Smoking in tuberculosis patients increases the risk of infection in their contacts

Pere Godoy, J. A. Caylà, G. Carmona, N. Camps, J. Álvarez, M. Alsedà, S. Minguell, A. Rodés, N. Altet, J. M. Pina, I. Barrabeig, À Orcau, I. Parron, J. March, N. Follia, M. Sabater, À Domínguez

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To determine the risk of latent tuberculous infection (LTBI) among contacts of smokers with tuberculosis (TB). METHODS: A study was conducted to determine the prevalence of LTBI among contacts of TB cases aged >14 years in Catalonia, Spain. A survey was carried out for each TB case and their contacts. LTBI was diagnosed using the tuberculin skin test (≥5 mm). The risk of LTBI associated with smoking was determined by multivariate logistic regression analysis, with adjusted odds ratio (aOR) and their 95% confidence intervals (CI). RESULTS: The smoking prevalence among TB cases was 40.7% (439/1079). The prevalence of LTBI among their contacts was 29.7% (2281/7673). It was higher among contacts of smoking index cases (35.3%) than among those of non-smokers (25.7%). Smoking was independently associated with an increased risk of LTBI among contacts (aOR 1.5, 95%CI 1.3-1.7), and was estimated to be responsible for 12.8% of infections. CONCLUSIONS: Index case smoking increases the risk of LTBI and should be systematically investigated. A reduction in smoking could lower the risk of infection substantially.

Original language	English (US)
Pages (from-to)	771-776
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	17
Issue number	6
DOIs	https://doi.org/10.5588/ijtld.12.0696
State	Published - Jun 1 2013

Keywords

Contact tracing
Latent tuberculosis infection
Prevalence
Smoking
Transmission

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

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10.5588/ijtld.12.0696

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Godoy, P., Caylà, J. A., Carmona, G., Camps, N., Álvarez, J., Alsedà, M., Minguell, S., Rodés, A., Altet, N., Pina, J. M., Barrabeig, I., Orcau, À., Parron, I., March, J., Follia, N., Sabater, M., & Domínguez, À. (2013). Smoking in tuberculosis patients increases the risk of infection in their contacts. International Journal of Tuberculosis and Lung Disease, 17(6), 771-776. https://doi.org/10.5588/ijtld.12.0696

Smoking in tuberculosis patients increases the risk of infection in their contacts. / Godoy, Pere; Caylà, J. A.; Carmona, G.; Camps, N.; Álvarez, J.; Alsedà, M.; Minguell, S.; Rodés, A.; Altet, N.; Pina, J. M.; Barrabeig, I.; Orcau, À; Parron, I.; March, J.; Follia, N.; Sabater, M.; Domínguez, À.

In: International Journal of Tuberculosis and Lung Disease, Vol. 17, No. 6, 01.06.2013, p. 771-776.

Research output: Contribution to journal › Article › peer-review

Godoy, P, Caylà, JA, Carmona, G, Camps, N, Álvarez, J, Alsedà, M, Minguell, S, Rodés, A, Altet, N, Pina, JM, Barrabeig, I, Orcau, À, Parron, I, March, J, Follia, N, Sabater, M & Domínguez, À 2013, 'Smoking in tuberculosis patients increases the risk of infection in their contacts', International Journal of Tuberculosis and Lung Disease, vol. 17, no. 6, pp. 771-776. https://doi.org/10.5588/ijtld.12.0696

Godoy, Pere ; Caylà, J. A. ; Carmona, G. ; Camps, N. ; Álvarez, J. ; Alsedà, M. ; Minguell, S. ; Rodés, A. ; Altet, N. ; Pina, J. M. ; Barrabeig, I. ; Orcau, À ; Parron, I. ; March, J. ; Follia, N. ; Sabater, M. ; Domínguez, À. / Smoking in tuberculosis patients increases the risk of infection in their contacts. In: International Journal of Tuberculosis and Lung Disease. 2013 ; Vol. 17, No. 6. pp. 771-776.

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abstract = "OBJECTIVE: To determine the risk of latent tuberculous infection (LTBI) among contacts of smokers with tuberculosis (TB). METHODS: A study was conducted to determine the prevalence of LTBI among contacts of TB cases aged >14 years in Catalonia, Spain. A survey was carried out for each TB case and their contacts. LTBI was diagnosed using the tuberculin skin test (≥5 mm). The risk of LTBI associated with smoking was determined by multivariate logistic regression analysis, with adjusted odds ratio (aOR) and their 95% confidence intervals (CI). RESULTS: The smoking prevalence among TB cases was 40.7% (439/1079). The prevalence of LTBI among their contacts was 29.7% (2281/7673). It was higher among contacts of smoking index cases (35.3%) than among those of non-smokers (25.7%). Smoking was independently associated with an increased risk of LTBI among contacts (aOR 1.5, 95%CI 1.3-1.7), and was estimated to be responsible for 12.8% of infections. CONCLUSIONS: Index case smoking increases the risk of LTBI and should be systematically investigated. A reduction in smoking could lower the risk of infection substantially.",

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AU - Carmona, G.

AU - Camps, N.

AU - Álvarez, J.

AU - Alsedà, M.

AU - Minguell, S.

AU - Rodés, A.

AU - Altet, N.

AU - Pina, J. M.

AU - Barrabeig, I.

AU - Orcau, À

AU - Parron, I.

AU - March, J.

AU - Follia, N.

AU - Sabater, M.

AU - Domínguez, À

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AB - OBJECTIVE: To determine the risk of latent tuberculous infection (LTBI) among contacts of smokers with tuberculosis (TB). METHODS: A study was conducted to determine the prevalence of LTBI among contacts of TB cases aged >14 years in Catalonia, Spain. A survey was carried out for each TB case and their contacts. LTBI was diagnosed using the tuberculin skin test (≥5 mm). The risk of LTBI associated with smoking was determined by multivariate logistic regression analysis, with adjusted odds ratio (aOR) and their 95% confidence intervals (CI). RESULTS: The smoking prevalence among TB cases was 40.7% (439/1079). The prevalence of LTBI among their contacts was 29.7% (2281/7673). It was higher among contacts of smoking index cases (35.3%) than among those of non-smokers (25.7%). Smoking was independently associated with an increased risk of LTBI among contacts (aOR 1.5, 95%CI 1.3-1.7), and was estimated to be responsible for 12.8% of infections. CONCLUSIONS: Index case smoking increases the risk of LTBI and should be systematically investigated. A reduction in smoking could lower the risk of infection substantially.

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Smoking in tuberculosis patients increases the risk of infection in their contacts

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