Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups

A. V. Moorman, E. Roman, R. A. Cartwright, G. J. Morgan

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalBritish journal of cancer
Volume86
Issue number1
DOIs
StatePublished - Jan 7 2002
Externally publishedYes

Keywords

  • Acute myeloid leukaemia
  • Aetiology
  • Chromosomal abnormalities
  • Cytogenetics
  • Tobacco smoke

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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