@article{e0600aed93f046508e4cdac137778ae3,
title = "Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups",
abstract = "Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.",
keywords = "Acute myeloid leukaemia, Aetiology, Chromosomal abnormalities, Cytogenetics, Tobacco smoke",
author = "Moorman, {A. V.} and E. Roman and Cartwright, {R. A.} and Morgan, {G. J.}",
note = "Funding Information: This work was supported by a research grant from the Leukaemia Research Fund. We thank the following for providing cytogenetic data: South West Regional Cytogenetics Centre, Bristol (Mrs C Kitchen); Cytogenetics Department, St James University Hospital, Leeds (Mrs H Dickinson); Oncology Cytogenetics Service, Christie Hospital, Manchester (Mr N Telford); Northern Genetics Service, Royal Victoria Infirmary, Newcastle-upon-Tyne (Mr N Bown); Wessex Regional Genetics Laboratory, Salisbury (Dr F Ross); Centre for Human Genetics, Sheffield (Ms A Watmore); Westlakes Research Institute, Cumbria (Mrs C Whitehouse) and the Medical Research Council Clinical Trials Service Unit, Oxford. We also thank all the consultants, hospital staff, general practitioners, interviewers and interviewees who participated in the case–control study. Eleanor Willett is also thanked for her comments on the manuscript.",
year = "2002",
month = jan,
day = "7",
doi = "10.1038/sj.bjc.6600010",
language = "English (US)",
volume = "86",
pages = "60--62",
journal = "British journal of cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "1",
}