Smoking and risk of tuberculosis incidence, mortality, and recurrence in South Korean men and women

Sun Ha Jee, Jonathan E Golub, Jaeseong Jo, Il Su Park, Heechoul Ohrr, Jonathan M. Samet

Research output: Contribution to journalArticle

Abstract

The authors explored the association of cigarette smoking with tuberculosis incidence, recurrence, and mortality. A 14-year prospective cohort study (1992-2006) was carried out in 1,294,504 South Koreans. Participants were grouped by smoking history, and the authors assessed tuberculosis incidence, mortality, and recurrence risk for each group. Unadjusted and adjusted Cox proportional hazards models were used to investigate the association between smoking history and the 3 outcomes of interest, adjusting for age and alcohol use. Compared with never smokers, current smokers had increased mortality from tuberculosis among both men (adjusted hazard ratio (HR)=1.6, 95% confidence interval (CI): 1.3, 2.0) and women (HR=1.6, 95% CI: 1.0, 2.4). Current male smokers had greater risk of incident tuberculosis than former smokers (HR=1.4, 95% CI: 1.3, 1.5), and risk among current smokers increased with number of cigarettes smoked daily. In females, cigarette smoking was not associated with incident tuberculosis. There was interaction between smoking and sex for incidence (P =0.00047). The effect of smoking was generally reduced with adjustment for body mass index. Among men, the highest alcohol consumption category (≥100 g/day) was associated with risk of incident tuberculosis (HR=1.5, 95% CI: 1.3, 1.7). This study provides longitudinal evidence that smoking increases risk of incident tuberculosis, mortality from tuberculosis, and tuberculosis recurrence.

Original languageEnglish (US)
Pages (from-to)1478-1485
Number of pages8
JournalAmerican Journal of Epidemiology
Volume170
Issue number12
DOIs
StatePublished - Dec 2009

Fingerprint

Tuberculosis
Smoking
Recurrence
Mortality
Incidence
Confidence Intervals
History
Proportional Hazards Models
Tobacco Products
Alcohol Drinking
Longitudinal Studies
Body Mass Index
Cohort Studies
Alcohols
Prospective Studies

Keywords

  • Alcohol drinking
  • Incidence
  • Mortality
  • Recurrence
  • Smoking
  • Tuberculosis

ASJC Scopus subject areas

  • Epidemiology

Cite this

Smoking and risk of tuberculosis incidence, mortality, and recurrence in South Korean men and women. / Jee, Sun Ha; Golub, Jonathan E; Jo, Jaeseong; Park, Il Su; Ohrr, Heechoul; Samet, Jonathan M.

In: American Journal of Epidemiology, Vol. 170, No. 12, 12.2009, p. 1478-1485.

Research output: Contribution to journalArticle

Jee, Sun Ha ; Golub, Jonathan E ; Jo, Jaeseong ; Park, Il Su ; Ohrr, Heechoul ; Samet, Jonathan M. / Smoking and risk of tuberculosis incidence, mortality, and recurrence in South Korean men and women. In: American Journal of Epidemiology. 2009 ; Vol. 170, No. 12. pp. 1478-1485.
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