TY - JOUR
T1 - Smoking, alcohol use disorder and tuberculosis treatment outcomes
T2 - A dual comorbidity burden that cannot be ignored
AU - for the CTRIUMPH-RePORT India Study
AU - Thomas, Beena Elizabeth
AU - Thiruvengadam, Kannan
AU - Rani, S.
AU - Kadam, Dileep
AU - Ovung, Senthanro
AU - Sivakumar, Shrutha
AU - Shivakumar, Shri Vijay Bala Yogendra
AU - Paradkar, Mandar
AU - Gupte, Nikhil
AU - Suryavanshi, Nishi
AU - Dolla, C. K.
AU - Gupte, Akshay N.
AU - Kohli, Rewa
AU - Pradhan, Neeta
AU - Sivaramakrishnan, Gomathi Narayan
AU - Gaikwad, Sanjay
AU - Kagal, Anju
AU - Dhanasekaran, Kavitha
AU - Deluca, Andrea
AU - Golub, Jonathan E.
AU - Mave, Vidya
AU - Chandrasekaran, Padmapriyadarshini
AU - Gupta, Amita
N1 - Publisher Copyright:
© 2019 Thomas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of increasing tobacco dose, relevance of alcohol misuse and past versus current or never smoking status on TB treatment outcomes remain inadequately defined. Methods We conducted a multi-centric prospective cohort study of newly diagnosed adult pulmonary TB patients initiated on TB treatment and followed for a minimum of 6 months to assess the impact of smoking status with or without alcohol abuse on treatment outcomes. Smokers were defined as never smokers, past smokers or current smokers. Alcohol Use Disorder Identification Test (AUDIT) scores were used to assess alcohol misuse. The association between smoking status and treatment outcomes was assessed in univariate and multivariate random effects poisson regression models. Results Of 455 enrolled, 129 (28%) had a history of smoking with 94 (20%) current smokers and 35 (8%) past smokers. Unfavourable treatment outcomes were significantly higher among past and current smokers as compared to never smokers. Specifically, the risk of treatment failure was significantly higher among past smokers (aIRR = 2.66, 95% CI: 1.41–4.90, p = 0.002), recurrent TB among current smokers (aIRR = 2.94, 95% CI: 1.30–6.67, p = 0.010) and death among both past (2.63, 95% CI: 1.11–6.24, p = 0.028) and current (aIRR = 2.59, 95% CI: 1.29–5.18, p = 0.007) smokers. Furthermore, the combined effect of alcohol misuse and smoking on unfavorable treatment outcomes was significantly higher among past smokers (aIRR: 4.67, 95% CI: 2.17–10.02, p<0.001) and current smokers (aIRR: 3.58, 95% CI: 1.89–6.76, p<0.001). Conclusion Past and current smoking along with alcohol misuse have combined effects on increasing the risk of unfavourable TB treatment outcomes. Innovative interventions that can readily address both co-morbidities are urgently needed.
AB - Background More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of increasing tobacco dose, relevance of alcohol misuse and past versus current or never smoking status on TB treatment outcomes remain inadequately defined. Methods We conducted a multi-centric prospective cohort study of newly diagnosed adult pulmonary TB patients initiated on TB treatment and followed for a minimum of 6 months to assess the impact of smoking status with or without alcohol abuse on treatment outcomes. Smokers were defined as never smokers, past smokers or current smokers. Alcohol Use Disorder Identification Test (AUDIT) scores were used to assess alcohol misuse. The association between smoking status and treatment outcomes was assessed in univariate and multivariate random effects poisson regression models. Results Of 455 enrolled, 129 (28%) had a history of smoking with 94 (20%) current smokers and 35 (8%) past smokers. Unfavourable treatment outcomes were significantly higher among past and current smokers as compared to never smokers. Specifically, the risk of treatment failure was significantly higher among past smokers (aIRR = 2.66, 95% CI: 1.41–4.90, p = 0.002), recurrent TB among current smokers (aIRR = 2.94, 95% CI: 1.30–6.67, p = 0.010) and death among both past (2.63, 95% CI: 1.11–6.24, p = 0.028) and current (aIRR = 2.59, 95% CI: 1.29–5.18, p = 0.007) smokers. Furthermore, the combined effect of alcohol misuse and smoking on unfavorable treatment outcomes was significantly higher among past smokers (aIRR: 4.67, 95% CI: 2.17–10.02, p<0.001) and current smokers (aIRR: 3.58, 95% CI: 1.89–6.76, p<0.001). Conclusion Past and current smoking along with alcohol misuse have combined effects on increasing the risk of unfavourable TB treatment outcomes. Innovative interventions that can readily address both co-morbidities are urgently needed.
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U2 - 10.1371/journal.pone.0220507
DO - 10.1371/journal.pone.0220507
M3 - Article
C2 - 31365583
AN - SCOPUS:85070876049
SN - 1932-6203
VL - 14
JO - PloS one
JF - PloS one
IS - 7
M1 - e0220507
ER -