SmartTots Outcomes Workshop 2017: Notes from a Round Table Discussion about Outcome Measures

William M. Jackson, Aston K. McCullough, Virginia Rauh, Cynthia F Salorio

Research output: Contribution to journalArticle

Abstract

An important element of designing research studies is the selection of appropriate outcome measures to ensure that the question posed is properly answered given the evidence. The selection of outcome measures is especially important when tackling complex, interdisciplinary problems, where appropriate outcome measures may not be as simple as a blood test or a laboratory value. One such area of study is the research into neurodevelopmental outcomes after early exposure to anesthetic agents. Concern has arisen recently that certain anesthetic agents may be toxic to the developing brain; a public-private partnership, SmartTots, was formed in conjunction with the Food and Drug Administration and various stakeholders to develop safe anesthetic regimens for neonates and infants who require surgery. However, as research has progressed, questions have arisen regarding the best outcome measures to use in order to detect a true effect, as well as the optimal window in which to measure. These issues were discussed in a round table meeting during the SmartTots meeting in September 2017, and a summary of the discussion is presented here.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalJournal of Neurosurgical Anesthesiology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Outcome Assessment (Health Care)
Anesthetics
Education
Research
Public-Private Sector Partnerships
Poisons
Hematologic Tests
United States Food and Drug Administration
Newborn Infant
Brain

Keywords

  • anesthesia
  • neurodevelopment
  • neurotoxicity
  • outcomes
  • SmartTots
  • standardized

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

SmartTots Outcomes Workshop 2017 : Notes from a Round Table Discussion about Outcome Measures. / Jackson, William M.; McCullough, Aston K.; Rauh, Virginia; Salorio, Cynthia F.

In: Journal of Neurosurgical Anesthesiology, Vol. 31, No. 1, 01.01.2019, p. 115-118.

Research output: Contribution to journalArticle

Jackson, William M. ; McCullough, Aston K. ; Rauh, Virginia ; Salorio, Cynthia F. / SmartTots Outcomes Workshop 2017 : Notes from a Round Table Discussion about Outcome Measures. In: Journal of Neurosurgical Anesthesiology. 2019 ; Vol. 31, No. 1. pp. 115-118.
@article{0faee1b0e8c9494bb23efdd38b73f269,
title = "SmartTots Outcomes Workshop 2017: Notes from a Round Table Discussion about Outcome Measures",
abstract = "An important element of designing research studies is the selection of appropriate outcome measures to ensure that the question posed is properly answered given the evidence. The selection of outcome measures is especially important when tackling complex, interdisciplinary problems, where appropriate outcome measures may not be as simple as a blood test or a laboratory value. One such area of study is the research into neurodevelopmental outcomes after early exposure to anesthetic agents. Concern has arisen recently that certain anesthetic agents may be toxic to the developing brain; a public-private partnership, SmartTots, was formed in conjunction with the Food and Drug Administration and various stakeholders to develop safe anesthetic regimens for neonates and infants who require surgery. However, as research has progressed, questions have arisen regarding the best outcome measures to use in order to detect a true effect, as well as the optimal window in which to measure. These issues were discussed in a round table meeting during the SmartTots meeting in September 2017, and a summary of the discussion is presented here.",
keywords = "anesthesia, neurodevelopment, neurotoxicity, outcomes, SmartTots, standardized",
author = "Jackson, {William M.} and McCullough, {Aston K.} and Virginia Rauh and Salorio, {Cynthia F}",
year = "2019",
month = "1",
day = "1",
doi = "10.1097/ANA.0000000000000550",
language = "English (US)",
volume = "31",
pages = "115--118",
journal = "Journal of Neurosurgical Anesthesiology",
issn = "0898-4921",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - SmartTots Outcomes Workshop 2017

T2 - Notes from a Round Table Discussion about Outcome Measures

AU - Jackson, William M.

AU - McCullough, Aston K.

AU - Rauh, Virginia

AU - Salorio, Cynthia F

PY - 2019/1/1

Y1 - 2019/1/1

N2 - An important element of designing research studies is the selection of appropriate outcome measures to ensure that the question posed is properly answered given the evidence. The selection of outcome measures is especially important when tackling complex, interdisciplinary problems, where appropriate outcome measures may not be as simple as a blood test or a laboratory value. One such area of study is the research into neurodevelopmental outcomes after early exposure to anesthetic agents. Concern has arisen recently that certain anesthetic agents may be toxic to the developing brain; a public-private partnership, SmartTots, was formed in conjunction with the Food and Drug Administration and various stakeholders to develop safe anesthetic regimens for neonates and infants who require surgery. However, as research has progressed, questions have arisen regarding the best outcome measures to use in order to detect a true effect, as well as the optimal window in which to measure. These issues were discussed in a round table meeting during the SmartTots meeting in September 2017, and a summary of the discussion is presented here.

AB - An important element of designing research studies is the selection of appropriate outcome measures to ensure that the question posed is properly answered given the evidence. The selection of outcome measures is especially important when tackling complex, interdisciplinary problems, where appropriate outcome measures may not be as simple as a blood test or a laboratory value. One such area of study is the research into neurodevelopmental outcomes after early exposure to anesthetic agents. Concern has arisen recently that certain anesthetic agents may be toxic to the developing brain; a public-private partnership, SmartTots, was formed in conjunction with the Food and Drug Administration and various stakeholders to develop safe anesthetic regimens for neonates and infants who require surgery. However, as research has progressed, questions have arisen regarding the best outcome measures to use in order to detect a true effect, as well as the optimal window in which to measure. These issues were discussed in a round table meeting during the SmartTots meeting in September 2017, and a summary of the discussion is presented here.

KW - anesthesia

KW - neurodevelopment

KW - neurotoxicity

KW - outcomes

KW - SmartTots

KW - standardized

UR - http://www.scopus.com/inward/record.url?scp=85058543867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058543867&partnerID=8YFLogxK

U2 - 10.1097/ANA.0000000000000550

DO - 10.1097/ANA.0000000000000550

M3 - Article

C2 - 30767933

AN - SCOPUS:85058543867

VL - 31

SP - 115

EP - 118

JO - Journal of Neurosurgical Anesthesiology

JF - Journal of Neurosurgical Anesthesiology

SN - 0898-4921

IS - 1

ER -