Smallpox vaccine

Jon S. Abramson, Carol J. Baker, Robert S. Baltimore, Margaret C. Fisher, Julia McMillan, H. Cody Meissner, Gary D. Overturf, Keith R. Powell, Charles G. Prober, Margaret B. Rennels, Thomas N. Saari, Larry K. Pickering, Edgar O. Ledbetter, Martha Cook

Research output: Contribution to journalArticle

Abstract

After an extensive worldwide eradication program, the last nonlaboratory case of smallpox occurred in 1977 in Somalia. In 1972, routine smallpox immunization was discontinued in the United States, and since 1983, vaccine production has been halted. Stockpiled vaccine has been used only for laboratory researchers working on orthopoxviruses. In recent years, there has been concern that smallpox virus stocks may be in the hands of bioterrorists, and this concern has been heightened by the terrorist attack on the World Trade Center and the Pentagon on September 11, 2001. Because most of the population is considered to be nonimmune, there is debate as to whether smallpox immunization should be resumed. This statement reviews the current status of smallpox vaccine, the adverse effects that were associated with smallpox vaccine in the past, and the major proposals for vaccine use. The statement provides the rationale for a policy based on the so-called ring vaccination strategy recommended by the Centers for Disease Control and Prevention, in which cases of smallpox are rapidly identified, infected individuals are isolated, and contacts of the infected individuals as well as their contacts are immunized immediately.

Original languageEnglish (US)
Pages (from-to)841-845
Number of pages5
JournalPediatrics
Volume110
Issue number4
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

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Smallpox Vaccine
Smallpox
Vaccines
Immunization
Variola virus
Orthopoxvirus
Somalia
Centers for Disease Control and Prevention (U.S.)
Vaccination
Research Personnel
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Abramson, J. S., Baker, C. J., Baltimore, R. S., Fisher, M. C., McMillan, J., Meissner, H. C., ... Cook, M. (2002). Smallpox vaccine. Pediatrics, 110(4), 841-845. https://doi.org/10.1542/peds.110.4.841

Smallpox vaccine. / Abramson, Jon S.; Baker, Carol J.; Baltimore, Robert S.; Fisher, Margaret C.; McMillan, Julia; Meissner, H. Cody; Overturf, Gary D.; Powell, Keith R.; Prober, Charles G.; Rennels, Margaret B.; Saari, Thomas N.; Pickering, Larry K.; Ledbetter, Edgar O.; Cook, Martha.

In: Pediatrics, Vol. 110, No. 4, 01.10.2002, p. 841-845.

Research output: Contribution to journalArticle

Abramson, JS, Baker, CJ, Baltimore, RS, Fisher, MC, McMillan, J, Meissner, HC, Overturf, GD, Powell, KR, Prober, CG, Rennels, MB, Saari, TN, Pickering, LK, Ledbetter, EO & Cook, M 2002, 'Smallpox vaccine', Pediatrics, vol. 110, no. 4, pp. 841-845. https://doi.org/10.1542/peds.110.4.841
Abramson JS, Baker CJ, Baltimore RS, Fisher MC, McMillan J, Meissner HC et al. Smallpox vaccine. Pediatrics. 2002 Oct 1;110(4):841-845. https://doi.org/10.1542/peds.110.4.841
Abramson, Jon S. ; Baker, Carol J. ; Baltimore, Robert S. ; Fisher, Margaret C. ; McMillan, Julia ; Meissner, H. Cody ; Overturf, Gary D. ; Powell, Keith R. ; Prober, Charles G. ; Rennels, Margaret B. ; Saari, Thomas N. ; Pickering, Larry K. ; Ledbetter, Edgar O. ; Cook, Martha. / Smallpox vaccine. In: Pediatrics. 2002 ; Vol. 110, No. 4. pp. 841-845.
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