Small vessel disease and the resting functional architecture of the brain

Robert D. Stevens, Yousef Hannawi, Haris Sair

Research output: Contribution to journalReview articlepeer-review


Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor tensor imaging studies, these data support of a model of disrupted connectivity as a systems-level approach to the cognitive disturbances seen in SVD.

Original languageEnglish (US)
Pages (from-to)1089-1090
Number of pages2
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number7
StatePublished - Jul 2014


  • cognitive impairment
  • dementia
  • fMRI
  • functional connectivity
  • resting state
  • small vessel disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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