Small vessel disease and the resting functional architecture of the brain

Robert D. Stevens; Yousef Hannawi; Haris Sair

doi:10.1038/jcbfm.2014.69

Small vessel disease and the resting functional architecture of the brain

Robert D. Stevens, Yousef Hannawi, Haris Sair

School of Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor tensor imaging studies, these data support of a model of disrupted connectivity as a systems-level approach to the cognitive disturbances seen in SVD.

Original language	English (US)
Pages (from-to)	1089-1090
Number of pages	2
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	34
Issue number	7
DOIs	https://doi.org/10.1038/jcbfm.2014.69
State	Published - Jul 2014

Keywords

cognitive impairment
dementia
fMRI
functional connectivity
resting state
small vessel disease

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2014.69

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Small vessel disease and the resting functional architecture of the brain

Abstract

Keywords

ASJC Scopus subject areas

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