TY - JOUR
T1 - Small planum temporale volume in Down's syndrome
T2 - A volumetric MRI study
AU - Frangou, Sophia
AU - Aylward, Elizabeth
AU - Warren, Andrew
AU - Sharma, Tonmoy
AU - Barta, Patrick
AU - Pearlson, Godfrey
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997/10
Y1 - 1997/10
N2 - Objective: Down's syndrome is associated with structural brain abnormalities and language deficits. The aim of this study was to investigate whether the superior temporal gyrus and the planum temporale, both parts of the anatomic substrate for language, are abnormal in Down's syndrome. Method: The authors examined volumetric magnetic resonance imaging (MRI) measures of the superior temporal gyrus and the planum temporale for 17 community- dwelling patients with Down's syndrome and 17 matched healthy comparison subjects. For the subjects with Down 's syndrome, the correlations of the superior temporal gyrus and planum temporale volumes with performance on tests of language function were examined. Results: The planum temporale volume of the patients with Down's syndrome was smaller than that of the healthy subjects, even after differences in whole brain volume were controlled for. The volume of the superior temporal gyms in the Down's syndrome patients was proportionally similar to that of the comparison group. For the subjects with Down's syndrome, neither superior temporal gyrus nor planum temporale volume was significantly correlated with performance on language tests after total brain volume was controlled for. Conclusions: In Down's syndrome, planum temporale volume may be selectively smaller than normal, although the effect of this volume deficit on language is not clear.
AB - Objective: Down's syndrome is associated with structural brain abnormalities and language deficits. The aim of this study was to investigate whether the superior temporal gyrus and the planum temporale, both parts of the anatomic substrate for language, are abnormal in Down's syndrome. Method: The authors examined volumetric magnetic resonance imaging (MRI) measures of the superior temporal gyrus and the planum temporale for 17 community- dwelling patients with Down's syndrome and 17 matched healthy comparison subjects. For the subjects with Down 's syndrome, the correlations of the superior temporal gyrus and planum temporale volumes with performance on tests of language function were examined. Results: The planum temporale volume of the patients with Down's syndrome was smaller than that of the healthy subjects, even after differences in whole brain volume were controlled for. The volume of the superior temporal gyms in the Down's syndrome patients was proportionally similar to that of the comparison group. For the subjects with Down's syndrome, neither superior temporal gyrus nor planum temporale volume was significantly correlated with performance on language tests after total brain volume was controlled for. Conclusions: In Down's syndrome, planum temporale volume may be selectively smaller than normal, although the effect of this volume deficit on language is not clear.
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U2 - 10.1176/ajp.154.10.1424
DO - 10.1176/ajp.154.10.1424
M3 - Article
C2 - 9326826
AN - SCOPUS:0030848690
SN - 0002-953X
VL - 154
SP - 1424
EP - 1429
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 10
ER -