Small-molecule end-groups of linear polymer determine cell-type gene-delivery efficacy

Joel Sunshine, Jordan J. Green, Kerry P. Mahon, Fan Yang, Ahmed A. Eltoukhy, David N. Nguyen, Robert Langer, Daniel G. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented). End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective (see image).

Original languageEnglish (US)
Pages (from-to)4947-4951
Number of pages5
JournalAdvanced Materials
Volume21
Issue number48
DOIs
StatePublished - Dec 28 2009

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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