@article{6f534a042da24ce8accd8029b30569f9,
title = "Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): Multifunctional proteins in cancer",
abstract = "Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.",
author = "Akeila Bellahc{\`e}ne and Vincent Castronovo and Ogbureke, {Kalu U.E.} and Fisher, {Larry W.} and Fedarko, {Neal S.}",
note = "Funding Information: The work of A.B. and V.C. is supported by grants from the National Fund for Scientific Research (Belgium), the Centre Anti-Canc{\'e}reux of the University of Li{\`e}ge and the European Commission through METABRE Contract CEE LSHC-CT-2004-503049. The work of K.O. is supported by National Institute of Dental and Craniofacial Research/ National Institutes of Health (NIH) Grant K23 017791-01A1, Medical College of Georgia Research Institute Grant STP 00105W005, and the Wendy Will Case Cancer Fund. The research of L.W.F. is supported by the Intramural Research Program of the NIH, Department of Health and Human Services. The work of N.S.F. is supported by grants from the National Cancer Institute (R21CA87311 and R01 CA113865) and from the Department of Defense Congressionally Directed Medical Research Program (W81XWH-04-1-0844 and BC010478).",
year = "2008",
month = mar,
doi = "10.1038/nrc2345",
language = "English (US)",
volume = "8",
pages = "212--226",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "3",
}