Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): Multifunctional proteins in cancer

Akeila Bellahcène, Vincent Castronovo, Kalu U.E. Ogbureke, Larry W. Fisher, Neal S. Fedarko

Research output: Contribution to journalReview articlepeer-review

Abstract

Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.

Original languageEnglish (US)
Pages (from-to)212-226
Number of pages15
JournalNature Reviews Cancer
Volume8
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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