Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels

Junko Sawada, Takeo Urakami, Fangfei Li, Akane Urakami, Weiquan Zhu, Minoru Fukuda, Dean Y. Li, Erkki Ruoslahti, Masanobu Komatsu

Research output: Contribution to journalArticlepeer-review

Abstract

We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association with nascent blood vessels. Thus, R-Ras promotes normalization of the tumor vasculature. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization.

Original languageEnglish (US)
Pages (from-to)235-249
Number of pages15
JournalCancer cell
Volume22
Issue number2
DOIs
StatePublished - Aug 14 2012
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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