Small changes in expression affect predisposition to tumorigenesis

Hai Yan, Zuzana Dobbie, Stephen B. Gruber, Sanford Markowitz, Kathy Romans, Francis M Giardiello, Kenneth W Kinzler, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

Original languageEnglish (US)
Pages (from-to)25-26
Number of pages2
JournalNature Genetics
Volume30
Issue number1
DOIs
StatePublished - Jan 2002

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Adenomatous Polyposis Coli
Carcinogenesis
Tumor Suppressor Genes
Alleles
Gene Expression

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Small changes in expression affect predisposition to tumorigenesis. / Yan, Hai; Dobbie, Zuzana; Gruber, Stephen B.; Markowitz, Sanford; Romans, Kathy; Giardiello, Francis M; Kinzler, Kenneth W; Vogelstein, Bert.

In: Nature Genetics, Vol. 30, No. 1, 01.2002, p. 25-26.

Research output: Contribution to journalArticle

Yan, Hai ; Dobbie, Zuzana ; Gruber, Stephen B. ; Markowitz, Sanford ; Romans, Kathy ; Giardiello, Francis M ; Kinzler, Kenneth W ; Vogelstein, Bert. / Small changes in expression affect predisposition to tumorigenesis. In: Nature Genetics. 2002 ; Vol. 30, No. 1. pp. 25-26.
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