Small animal radiation research platform: imaging, mechanics, control and calibration.

Mohammad Matinfar, Owen Gray, Iulian Iordachita, Chris Kennedy, Eric Ford, John Wong, Russell H Taylor, Peter Kazanzides

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In cancer research, well characterized small animal models of human cancer, such as transgenic mice, have greatly accelerated the pace of development of cancer treatments. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those same models available for the development and evaluation of novel radiation therapies. In combination with advanced imaging methods, small animal research allows detailed study of biological processes, disease progression, and response to therapy, with the potential to provide a natural bridge to the clinical environment. The SARRP will realistically model human radiation treatment methods in standard animal models. In this paper, we describe the mechanical and control structure of the system. This system requires accurate calibration of the x-ray beam for both imaging and radiation treatment, which is presented in detail in the paper.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages926-934
Number of pages9
Volume10
EditionPt 2
Publication statusPublished - 2007

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matinfar, M., Gray, O., Iordachita, I., Kennedy, C., Ford, E., Wong, J., ... Kazanzides, P. (2007). Small animal radiation research platform: imaging, mechanics, control and calibration. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 2 ed., Vol. 10, pp. 926-934)