Small-angle neutron scattering of bilayer vesicles made with synthetic phospholipids

S. F. Trevino, Robert Ivkov, Gary R. Matyas, Frank J. Lebeda

Research output: Contribution to journalConference articlepeer-review

Abstract

We have used Small-Angle Neutron Scattering to investigate the structure of bilayer lipid membranes in aqueous solution. The lipids consist of equimolar concentrations of two molecules DMPG and DMPC (see text). The structures consist of solvent filled cores surrounded by shells composed of the lipid bilayers. In particular the radii of the core and shell thickness are measured as a function of lipid concentration and temperature. Other features which reveal themselves are vesicle forming ability of the lipids, additional larger structures and inter-vesicle interactions at large vesicle concentrations. The study is motivated by the possible use of these systems as delivery vehicles for various beneficial therapeutic compounds.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
Volume550
StatePublished - Jan 1 1999
Externally publishedYes
EventProceedings of the 1998 MRS Fall Meeting - The Symposium 'Advanced Catalytic Materials-1998' - Boston, MA, USA
Duration: Nov 30 1998Dec 3 1998

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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