Slow viral infections of the nervous system and genetic disease.

L. P. Weiner, Richard Johnson

Research output: Contribution to journalArticle

Abstract

Slow viral infections are characterized by a long incubation period, protracted clinical course, and limited host range. Scrapie of sheep and kuru and Creutzfeldt-Jakob disease of man are slow infections which have been regarded at one time or another as being of genetic etiology. The initial assumption that these represented hereodofamilial degenerative diseases came from their occurrence in families or in population aggregates, their chronic afebrile clinical courses and their histopathologic changes of noninflammatory degeneration. The role of genetics in these diseases is uncertain although in scrapie genetic susceptibility appears important in the natural infection. A more intimate virus-gene interrelationship in the form of a temperate infection has been postulated; however, little evidence exists at this time to support this hypothesis.

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalBirth Defects: Original Article Series
Volume7
Issue number1
StatePublished - Feb 1971
Externally publishedYes

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Inborn Genetic Diseases
Virus Diseases
Nervous System Diseases
Scrapie
Kuru
Infection
Creutzfeldt-Jakob Syndrome
Host Specificity
Genetic Predisposition to Disease
Sheep
Viruses
Population
Genes

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)

Cite this

Slow viral infections of the nervous system and genetic disease. / Weiner, L. P.; Johnson, Richard.

In: Birth Defects: Original Article Series, Vol. 7, No. 1, 02.1971, p. 72-77.

Research output: Contribution to journalArticle

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