TY - JOUR
T1 - slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C EBP
AU - Montell, Denise J.
AU - Rorth, Pernille
AU - Spradling, Allan C.
N1 - Funding Information:
‘We would like to thank Mike Sepanski for help with the electron microscopy and Cynthia Andrews for sequencing the Drosophila virilis gene and for other technical assistance. Special thanks to Steve McKnight for many helpful discussions. D. J. M. is a Lucille P. Markey Scholar and this work was supported in part by a grant from the Lucille P. Markey Charitable Trust, in part by National Institutes of Health grant R29GM46425. and by a Danish Medical Research Council fellowship to P. R. In addition, A. C. S. is a Howard Hughes Medical Institute Investigator.
PY - 1992/10/2
Y1 - 1992/10/2
N2 - During Drosophila oogenesis six to ten follicle cells, the border cells, undergo a dramatic and stereotypic migration through the developing egg chamber. We identified four independent P element insertion mutations that specifically blocked border cell migration. They defined a single, novel locus that was named slow border cells (slbo), because hypomorphic alleles caused delayed onset of the migration. Laser ablation of the border cells, or failure of their migration, caused improper morphogenesis of the micropyle, the eggshell structure through which the sperm enters at fertilization. The slbo locus was found to encode a product homologous to the CCAAT/enhancer-binding protein ( C EBP), a basic region-leucine zipper transcription factor. Drosophila C EBP may be required for the expression of gene products mediating border cell migration.
AB - During Drosophila oogenesis six to ten follicle cells, the border cells, undergo a dramatic and stereotypic migration through the developing egg chamber. We identified four independent P element insertion mutations that specifically blocked border cell migration. They defined a single, novel locus that was named slow border cells (slbo), because hypomorphic alleles caused delayed onset of the migration. Laser ablation of the border cells, or failure of their migration, caused improper morphogenesis of the micropyle, the eggshell structure through which the sperm enters at fertilization. The slbo locus was found to encode a product homologous to the CCAAT/enhancer-binding protein ( C EBP), a basic region-leucine zipper transcription factor. Drosophila C EBP may be required for the expression of gene products mediating border cell migration.
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U2 - 10.1016/0092-8674(92)90265-E
DO - 10.1016/0092-8674(92)90265-E
M3 - Article
C2 - 1394432
AN - SCOPUS:0026701816
SN - 0092-8674
VL - 71
SP - 51
EP - 62
JO - Cell
JF - Cell
IS - 1
ER -