Slit-robo signaling in ocular angiogenesis

Haoyu Chen, Mingzhi Zhang, Shibo Tang, Nyall R. London, Dean Y. Li, Kang Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

Slit-Robo signaling was firstly discovered as a major repellent pathway at the midline of the central nervous system. Intense investigation found that this pathway also plays an important role in other biological process including angiogenesis. Robo4 is the vascular endothelial cell specific member of Robo family. It was found that Slit-Robo signaling can inhibit endothelial cell migration, tube formation and vascular permeability. Slit-Robo signaling also plays an important role in embryonic and tumor angiogenesis. In animal model of ocular angiogenesis, addition of Slit inhibited laser induced choroidal neovascularization, oxygen induced retinopathy and VEGF induced retinal permeability in a Robo4 dependent manner. Recent data demonstrates that Robo1 and Robo4 form a heterodimer in endothelial cells, The role of this heterodimer in counteracting VEGF signaling is unknown. Further investigation is required to better understand Slit-Robo signaling and develop novel therapy for angiogenesis.

Original languageEnglish (US)
Title of host publicationRetinal Degenerative Diseases
Subtitle of host publicationLaboratory and Therapeutic Investigations
EditorsRobert Anderson, Nawajes Mandal, Joe Hollyfield, Matthew LaVail
Pages457-463
Number of pages7
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume664
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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