SlimQuick™- associated hepatotoxicity in a woman with alpha-1 antitrypsin heterozygosity

Douglas H. Weinstein, William S. Twaddell, Jean Pierre Raufman, Benjamin Philosophe, Ayse L. Mindikoglu

Research output: Contribution to journalArticlepeer-review

Abstract

Green tea (Camellia sinensis)-associated hepatotoxicity is reported. However, the presence of alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated drug-induced liver injury (DILI) is unknown. A previously healthy woman with alpha-1 antitrypsin MZ phenotype who took SlimQuick ™, an herbal supplement containing green tea extract, developed severe hepatotoxicity requiring corticosteroid treatment. Green tea-associated hepatotoxicity is reviewed and alpha-1 antitrypsin MZ phenotype as a predisposing factor to green tea-associated DILI is discussed. Liver biopsy demonstrated marked inflammation with necrosis suggestive of toxic injury with diffuse alpha-1 antitrypsin globule deposition on immunostaining. Corticosteroid therapy resulted in rapid clinical improvement. Alpha-1 antitrypsin MZ phenotype may increase vulnerability to herbal hepatotoxicity.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalWorld Journal of Hepatology
Volume4
Issue number4
DOIs
StatePublished - 2012

Keywords

  • Alpha-1-antitrypsin MZ phenotype
  • Drug-induced liver injury
  • Green tea
  • Hepatotoxicity
  • SlimQuick™

ASJC Scopus subject areas

  • Hepatology

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