TY - JOUR
T1 - Sleep duration and subsequent cortical thinning in cognitively normal older adults
AU - Spira, Adam P.
AU - Gonzalez, Christopher E.
AU - Venkatraman, Vijay K.
AU - Wu, Mark N.
AU - Pacheco, Jennifer
AU - Simonsick, Eleanor M.
AU - Ferrucci, Luigi
AU - Resnick, Susan M.
N1 - Funding Information:
This study was supported in part by the Intramural Research Program (IRP), National Institute on Aging (NIA), National Institutes of Health (NIH) and by Research and Development Contract HHSN-260-2004-00012C. Dr. Spira was supported in part by 1K01AG033195 and by 1R01AG050507 from the National Institute on Aging and has received funding from the William and Ella Owens Medical Research Foundation. Investigators from the NIH, NIA, and IRP were involved in all aspects of this manuscript, including the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Dr. Resnick has an immediate family member who has received grant/research support from Takeda, Roche, Pfizer, Lundbeck, Johnson & Johnson, Intracellular, GE Healthcare, DART Neuroscience, Avid/Lilly, and Piramal Imaging. The other authors report no conflicts of interest. Results from this study were presented at the 2015 Annual Meeting of the Gerontological Society of America.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Study Objectives: To determine the association between self-reported sleep duration and cortical thinning among older adults. Methods: We studied 122 cognitively normal participants in the Baltimore Longitudinal Study of Aging with a mean age = 66.6 y (range, 51 84) at baseline sleep assessment and 69.5 y (range, 56 86) at initial magnetic resonance imaging (MRI) scan. Participants reported average sleep duration and completed a mean of 7.6 1.5-T MRI scans (range, 3 11), with mean follow-up from initial scan of 8.0 y (range, 2.0 11.8). Results: In analyses adjusted for age, sex, education, race, and interval between sleep assessment and initial MRI scan, participants reporting > 7 h sleep at baseline had thinner cortex in the inferior occipital gyrus and sulcus of the left hemisphere at initial MRI scan than those reporting 7 h (cluster P < 0.05). In adjusted longitudinal analyses, compared to those reporting 7 h of sleep, participants reporting < 7 h exhibited higher rates of subsequent thinning in the superior temporal sulcus and gyrus, inferior and middle frontal gyrus, and superior frontal sulcus of the left hemisphere, and in the superior frontal gyrus of the right hemisphere; those reporting > 7 h of sleep had higher rates of thinning in the superior frontal and middle frontal gyrus of the left hemisphere (cluster P < 0.05 for all). In sensitivity analyses, adjustment for apolipoprotein E (APOE) e4 genotype reduced or eliminated some effects but revealed others. When reports of < 7 h of sleep were compared to reports of 7 or 8 h combined, there were no significant associations with cortical thinning. Conclusions: Among cognitively normal older adults, sleep durations of < 7 h and > 7 h may increase the rate of subsequent frontotemporal gray matter atrophy. Additional studies, including those that use objective sleep measures and investigate mechanisms linking sleep duration to gray matter loss, are needed.
AB - Study Objectives: To determine the association between self-reported sleep duration and cortical thinning among older adults. Methods: We studied 122 cognitively normal participants in the Baltimore Longitudinal Study of Aging with a mean age = 66.6 y (range, 51 84) at baseline sleep assessment and 69.5 y (range, 56 86) at initial magnetic resonance imaging (MRI) scan. Participants reported average sleep duration and completed a mean of 7.6 1.5-T MRI scans (range, 3 11), with mean follow-up from initial scan of 8.0 y (range, 2.0 11.8). Results: In analyses adjusted for age, sex, education, race, and interval between sleep assessment and initial MRI scan, participants reporting > 7 h sleep at baseline had thinner cortex in the inferior occipital gyrus and sulcus of the left hemisphere at initial MRI scan than those reporting 7 h (cluster P < 0.05). In adjusted longitudinal analyses, compared to those reporting 7 h of sleep, participants reporting < 7 h exhibited higher rates of subsequent thinning in the superior temporal sulcus and gyrus, inferior and middle frontal gyrus, and superior frontal sulcus of the left hemisphere, and in the superior frontal gyrus of the right hemisphere; those reporting > 7 h of sleep had higher rates of thinning in the superior frontal and middle frontal gyrus of the left hemisphere (cluster P < 0.05 for all). In sensitivity analyses, adjustment for apolipoprotein E (APOE) e4 genotype reduced or eliminated some effects but revealed others. When reports of < 7 h of sleep were compared to reports of 7 or 8 h combined, there were no significant associations with cortical thinning. Conclusions: Among cognitively normal older adults, sleep durations of < 7 h and > 7 h may increase the rate of subsequent frontotemporal gray matter atrophy. Additional studies, including those that use objective sleep measures and investigate mechanisms linking sleep duration to gray matter loss, are needed.
KW - Aging
KW - Atrophy
KW - Cortical thinning
KW - Gray matter
KW - Neuroimaging
KW - Sleep duration
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U2 - 10.5665/sleep.5768
DO - 10.5665/sleep.5768
M3 - Article
C2 - 26951390
AN - SCOPUS:84965003781
SN - 0161-8105
VL - 39
SP - 1121
EP - 1128
JO - Sleep
JF - Sleep
IS - 5
ER -