Sleep Disorders and the Development of Insulin Resistance and Obesity

Omar Mesarwi, Jan Polak, Jonathan Jun, Vsevolod Polotsky

Research output: Contribution to journalArticle

Abstract

Normal sleep is characterized both by reduced glucose turnover by the brain and other metabolically active tissues, and by changes in glucose tolerance. Sleep duration has decreased over the last several decades; data suggest a link between short sleep duration and type 2 diabetes. Obstructive sleep apnea (OSA) results in intermittent hypoxia and sleep fragmentation, and also is associated with impaired glucose tolerance. Obesity is a major risk factor for OSA, but whether OSA leads to obesity is unclear. The quality and quantity of sleep may profoundly affect obesity and glucose tolerance, and should be routinely assessed by clinicians.

Original languageEnglish (US)
Pages (from-to)617-634
Number of pages18
JournalEndocrinology and Metabolism Clinics of North America
Volume42
Issue number3
DOIs
Publication statusPublished - Sep 2013

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Keywords

  • Diabetes
  • Glucose homeostasis
  • Metabolism
  • Obstructive sleep apnea
  • Sleep duration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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