Sleep disordered breathing risk in childhood cancer survivors: An exploratory study

Kathy Ruble, Anna George, Lisa Gallicchio, Charlene Gamaldo

Research output: Contribution to journalArticle

Abstract

Background: Sleep disordered breathing (SDB) is emerging as a significant health condition for children. The purpose of this study is to evaluate SDB symptoms in childhood cancer survivors and identify associations with quality of life (QOL) and psychological symptoms. Procedure: A sample of 62 survivors aged 8-18 years were recruited during routine survivorship visits. All subjects and their parents completed questionnaires to evaluate sleep, QOL and psychological symptoms; scales included were: Pediatric Sleep Questionnaire, Sleep Disordered Breathing Subscale (PSQ-SDBS), Pediatric Quality of Life Inventory (PedsQL) and Depression Anxiety Stress Scale (DASS-21). Continuous data were used for all scales and a threshold score of >0.33 on the PSA-SDBS was used to identify risk of SDB. The relationships between measures of sleep and independent variables were examined using Pearson correlations and multiple linear regression models for significant associations. Results: Of the 62 subjects enrolled, underlying diagnoses included 29 leukemias, 30 solid tumors and 3 non-malignant diseases. Nineteen percent of subjects were identified as having SDB risk on the PSQ-SDBS. The lowest mean PedsQL subscale score for parent and child ratings were school QOL; Parent mean 73(±SD 19) and Child mean 71(±SD 20). The severity of SDB per the PSQ was significantly associated with reduced total and school QOL which remained significant after adjusting for stress. Conclusions: Symptoms suggestive of SDB are common in childhood cancer survivors with negative implications for overall quality of life and school performance. Pediatr Blood Cancer 2015;62:693-697.

Original languageEnglish (US)
Pages (from-to)693-697
Number of pages5
JournalPediatric Blood and Cancer
Volume62
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Sleep Apnea Syndromes
Survivors
Quality of Life
Neoplasms
Sleep
Pediatrics
Linear Models
Psychology
Leukemia
Survival Rate
Anxiety
Parents
Depression
Equipment and Supplies

Keywords

  • Cancer survivor
  • Pediatric
  • Quality of life
  • Sleep disordered breathing

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Medicine(all)

Cite this

Sleep disordered breathing risk in childhood cancer survivors : An exploratory study. / Ruble, Kathy; George, Anna; Gallicchio, Lisa; Gamaldo, Charlene.

In: Pediatric Blood and Cancer, Vol. 62, No. 4, 01.04.2015, p. 693-697.

Research output: Contribution to journalArticle

@article{d0352176aa4446f18d4b61090e80390a,
title = "Sleep disordered breathing risk in childhood cancer survivors: An exploratory study",
abstract = "Background: Sleep disordered breathing (SDB) is emerging as a significant health condition for children. The purpose of this study is to evaluate SDB symptoms in childhood cancer survivors and identify associations with quality of life (QOL) and psychological symptoms. Procedure: A sample of 62 survivors aged 8-18 years were recruited during routine survivorship visits. All subjects and their parents completed questionnaires to evaluate sleep, QOL and psychological symptoms; scales included were: Pediatric Sleep Questionnaire, Sleep Disordered Breathing Subscale (PSQ-SDBS), Pediatric Quality of Life Inventory (PedsQL) and Depression Anxiety Stress Scale (DASS-21). Continuous data were used for all scales and a threshold score of >0.33 on the PSA-SDBS was used to identify risk of SDB. The relationships between measures of sleep and independent variables were examined using Pearson correlations and multiple linear regression models for significant associations. Results: Of the 62 subjects enrolled, underlying diagnoses included 29 leukemias, 30 solid tumors and 3 non-malignant diseases. Nineteen percent of subjects were identified as having SDB risk on the PSQ-SDBS. The lowest mean PedsQL subscale score for parent and child ratings were school QOL; Parent mean 73(±SD 19) and Child mean 71(±SD 20). The severity of SDB per the PSQ was significantly associated with reduced total and school QOL which remained significant after adjusting for stress. Conclusions: Symptoms suggestive of SDB are common in childhood cancer survivors with negative implications for overall quality of life and school performance. Pediatr Blood Cancer 2015;62:693-697.",
keywords = "Cancer survivor, Pediatric, Quality of life, Sleep disordered breathing",
author = "Kathy Ruble and Anna George and Lisa Gallicchio and Charlene Gamaldo",
year = "2015",
month = "4",
day = "1",
doi = "10.1002/pbc.25394",
language = "English (US)",
volume = "62",
pages = "693--697",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Sleep disordered breathing risk in childhood cancer survivors

T2 - An exploratory study

AU - Ruble, Kathy

AU - George, Anna

AU - Gallicchio, Lisa

AU - Gamaldo, Charlene

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: Sleep disordered breathing (SDB) is emerging as a significant health condition for children. The purpose of this study is to evaluate SDB symptoms in childhood cancer survivors and identify associations with quality of life (QOL) and psychological symptoms. Procedure: A sample of 62 survivors aged 8-18 years were recruited during routine survivorship visits. All subjects and their parents completed questionnaires to evaluate sleep, QOL and psychological symptoms; scales included were: Pediatric Sleep Questionnaire, Sleep Disordered Breathing Subscale (PSQ-SDBS), Pediatric Quality of Life Inventory (PedsQL) and Depression Anxiety Stress Scale (DASS-21). Continuous data were used for all scales and a threshold score of >0.33 on the PSA-SDBS was used to identify risk of SDB. The relationships between measures of sleep and independent variables were examined using Pearson correlations and multiple linear regression models for significant associations. Results: Of the 62 subjects enrolled, underlying diagnoses included 29 leukemias, 30 solid tumors and 3 non-malignant diseases. Nineteen percent of subjects were identified as having SDB risk on the PSQ-SDBS. The lowest mean PedsQL subscale score for parent and child ratings were school QOL; Parent mean 73(±SD 19) and Child mean 71(±SD 20). The severity of SDB per the PSQ was significantly associated with reduced total and school QOL which remained significant after adjusting for stress. Conclusions: Symptoms suggestive of SDB are common in childhood cancer survivors with negative implications for overall quality of life and school performance. Pediatr Blood Cancer 2015;62:693-697.

AB - Background: Sleep disordered breathing (SDB) is emerging as a significant health condition for children. The purpose of this study is to evaluate SDB symptoms in childhood cancer survivors and identify associations with quality of life (QOL) and psychological symptoms. Procedure: A sample of 62 survivors aged 8-18 years were recruited during routine survivorship visits. All subjects and their parents completed questionnaires to evaluate sleep, QOL and psychological symptoms; scales included were: Pediatric Sleep Questionnaire, Sleep Disordered Breathing Subscale (PSQ-SDBS), Pediatric Quality of Life Inventory (PedsQL) and Depression Anxiety Stress Scale (DASS-21). Continuous data were used for all scales and a threshold score of >0.33 on the PSA-SDBS was used to identify risk of SDB. The relationships between measures of sleep and independent variables were examined using Pearson correlations and multiple linear regression models for significant associations. Results: Of the 62 subjects enrolled, underlying diagnoses included 29 leukemias, 30 solid tumors and 3 non-malignant diseases. Nineteen percent of subjects were identified as having SDB risk on the PSQ-SDBS. The lowest mean PedsQL subscale score for parent and child ratings were school QOL; Parent mean 73(±SD 19) and Child mean 71(±SD 20). The severity of SDB per the PSQ was significantly associated with reduced total and school QOL which remained significant after adjusting for stress. Conclusions: Symptoms suggestive of SDB are common in childhood cancer survivors with negative implications for overall quality of life and school performance. Pediatr Blood Cancer 2015;62:693-697.

KW - Cancer survivor

KW - Pediatric

KW - Quality of life

KW - Sleep disordered breathing

UR - http://www.scopus.com/inward/record.url?scp=84923225017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923225017&partnerID=8YFLogxK

U2 - 10.1002/pbc.25394

DO - 10.1002/pbc.25394

M3 - Article

C2 - 25597930

AN - SCOPUS:84923225017

VL - 62

SP - 693

EP - 697

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 4

ER -