TY - JOUR
T1 - Sleep-Disordered Breathing and Metabolic Effects
T2 - Evidence from Animal Models
AU - Jun, Jonathan
AU - Polotsky, Vsevolod Y.
N1 - Funding Information:
This work was supported by National Heart, Lung, and Blood Institute Grants HL68715 and HL80105 to V.Y.P.
PY - 2007/6
Y1 - 2007/6
N2 - OSA, the most common form of sleep-disordered breathing, is characterized by recurrent collapse of the upper airway during sleep leading to periods of intermittent hypoxia and sleep fragmentation. There is growing evidence that OSA is associated with metabolic abnormalities and may be implicated in causality of metabolic disorders. OSA is linked to increased risk of hypertension, insulin resistance, glucose intolerance and type 2 diabetes, dyslipidemia, atherosclerosis, and non-alcoholic fatty liver disease, independent of underlying obesity. There are interactions between metabolic dysregulation and OSA that may lead to a vicious circle of cardiovascular and metabolic morbidity. The complexity of the relationship between metabolism and OSA can be scrutinized most effectively with animal models, which can account for all possible confounding factors.
AB - OSA, the most common form of sleep-disordered breathing, is characterized by recurrent collapse of the upper airway during sleep leading to periods of intermittent hypoxia and sleep fragmentation. There is growing evidence that OSA is associated with metabolic abnormalities and may be implicated in causality of metabolic disorders. OSA is linked to increased risk of hypertension, insulin resistance, glucose intolerance and type 2 diabetes, dyslipidemia, atherosclerosis, and non-alcoholic fatty liver disease, independent of underlying obesity. There are interactions between metabolic dysregulation and OSA that may lead to a vicious circle of cardiovascular and metabolic morbidity. The complexity of the relationship between metabolism and OSA can be scrutinized most effectively with animal models, which can account for all possible confounding factors.
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U2 - 10.1016/j.jsmc.2007.03.009
DO - 10.1016/j.jsmc.2007.03.009
M3 - Review article
C2 - 18516217
AN - SCOPUS:64749107053
SN - 1556-407X
VL - 2
SP - 263
EP - 277
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
IS - 2
ER -