Sleep apnea research in animals

Past, present, and future

Research output: Contribution to journalArticle

Abstract

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume54
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Sleep research
Sleep Apnea Syndromes
Obstructive Sleep Apnea
Animals
Sleep Deprivation
Sleep
History

Keywords

  • Animal
  • Fragmentation
  • Intermittent hypoxia
  • Sleep apnea

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Sleep apnea research in animals : Past, present, and future. / Chopra, Swati; Polotsky, Vsevolod; Jun, Jonathan.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 54, No. 3, 01.03.2016, p. 299-305.

Research output: Contribution to journalArticle

@article{1c8ff79d906848ddb1dc31596707f0c3,
title = "Sleep apnea research in animals: Past, present, and future",
abstract = "Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.",
keywords = "Animal, Fragmentation, Intermittent hypoxia, Sleep apnea",
author = "Swati Chopra and Vsevolod Polotsky and Jonathan Jun",
year = "2016",
month = "3",
day = "1",
doi = "10.1165/rcmb.2015-0218TR",
language = "English (US)",
volume = "54",
pages = "299--305",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "American Thoracic Society",
number = "3",

}

TY - JOUR

T1 - Sleep apnea research in animals

T2 - Past, present, and future

AU - Chopra, Swati

AU - Polotsky, Vsevolod

AU - Jun, Jonathan

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

AB - Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

KW - Animal

KW - Fragmentation

KW - Intermittent hypoxia

KW - Sleep apnea

UR - http://www.scopus.com/inward/record.url?scp=84963864719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963864719&partnerID=8YFLogxK

U2 - 10.1165/rcmb.2015-0218TR

DO - 10.1165/rcmb.2015-0218TR

M3 - Article

VL - 54

SP - 299

EP - 305

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 3

ER -