Sleep apnea research in animals: Past, present, and future

Research output: Contribution to journalArticle


Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of theupper airway during sleep.Animalmodelshave been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animalswith spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Issue number3
StatePublished - Mar 1 2016



  • Animal
  • Fragmentation
  • Intermittent hypoxia
  • Sleep apnea

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry

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