Sleep apnea in patients on conventional thrice-weekly hemodialysis

Comparison with matched controls from the sleep heart health study

Mark L. Unruh, Mark H. Sanders, Susan Redline, Beth M. Piraino, Jason G. Umans, Terese C. Hammond, Imran Sharief, Naresh M Punjabi, Anne B. Newman

Research output: Contribution to journalArticle

Abstract

Sleep-disordered breathing (SDB) has been noted commonly in hemodialysis (HD) patients, but it is not known whether this is related directly to the treatment of kidney failure with HD or to the higher prevalence of obesity and older age. Forty-six HD patients were compared with 137 participants from the Sleep Heart Health Study (SHHS) who were matched for age, gender, body mass index (BMI), and race. Home unattended polysomnography was performed and scored using similar protocols. The study sample was 62.7 ± 10.1 yr, was predominantly male (72%) and white (63%), and had an average BMI of 28 ± 5.3 kg/m2. The HD sample had a higher systolic BP (137 versus 121 mmHg; P <0.01) and a higher prevalence of diabetes (33 versus 9%; P <0.01) and cardiovascular disease (33 versus 13%; P <0.01) compared with the SHHS sample. The HD group had significantly less sleep time (320 versus 379 min; P <0.0001) but similar sleep efficiency. HD patients had a higher frequency of arousals per hour (25.1 versus 17.1; P <0.0001) and apnea-hypopneas per hour (27.2 versus 15.2; P <0.0001) and greater percentage of the total sleep time below an oxygen saturation of 90% (7.2 versus 1.8; P <0.0001). HD patients were more likely to have severe SDB (>30 respiratory events per hour) compared with the SHHS sample (odds ratio 4.07; 95% confidence interval 1.83 to 9.07). There was a strong association of HD with severe SDB and nocturnal hypoxemia independent of age, BMI, and the higher prevalence of chronic disease. The potential mechanisms for the higher likelihood of SDB in the HD population must be identified to provide specific prevention and therapy.

Original languageEnglish (US)
Pages (from-to)3503-3509
Number of pages7
JournalJournal of the American Society of Nephrology
Volume17
Issue number12
DOIs
StatePublished - Dec 2006

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Sleep Apnea Syndromes
Renal Dialysis
Sleep
Health
Body Mass Index
Polysomnography
Treatment Failure
Renal Insufficiency
Chronic Disease
Obesity
Odds Ratio
Confidence Intervals
Population

ASJC Scopus subject areas

  • Nephrology

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Sleep apnea in patients on conventional thrice-weekly hemodialysis : Comparison with matched controls from the sleep heart health study. / Unruh, Mark L.; Sanders, Mark H.; Redline, Susan; Piraino, Beth M.; Umans, Jason G.; Hammond, Terese C.; Sharief, Imran; Punjabi, Naresh M; Newman, Anne B.

In: Journal of the American Society of Nephrology, Vol. 17, No. 12, 12.2006, p. 3503-3509.

Research output: Contribution to journalArticle

Unruh, Mark L. ; Sanders, Mark H. ; Redline, Susan ; Piraino, Beth M. ; Umans, Jason G. ; Hammond, Terese C. ; Sharief, Imran ; Punjabi, Naresh M ; Newman, Anne B. / Sleep apnea in patients on conventional thrice-weekly hemodialysis : Comparison with matched controls from the sleep heart health study. In: Journal of the American Society of Nephrology. 2006 ; Vol. 17, No. 12. pp. 3503-3509.
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