Sleep and respiratory physiology in adults

Mudiaga Sowho, Jason Amatoury, Jason P. Kirkness, Susheel Patil

Research output: Contribution to journalArticle

Abstract

Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.

Original languageEnglish (US)
Pages (from-to)469-481
Number of pages13
JournalClinics in Chest Medicine
Volume35
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Respiratory Physiological Phenomena
Hypoventilation
Sleep
Respiration
Pharyngeal Muscles
Airway Resistance
Respiratory Muscles
Muscle Hypotonia
Posture
Population
Therapeutics

Keywords

  • Control of breathing
  • Hypoventilation
  • Lower airway
  • Respiratory physiology
  • Sleep effects
  • Upper airway

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Sleep and respiratory physiology in adults. / Sowho, Mudiaga; Amatoury, Jason; Kirkness, Jason P.; Patil, Susheel.

In: Clinics in Chest Medicine, Vol. 35, No. 3, 2014, p. 469-481.

Research output: Contribution to journalArticle

Sowho, Mudiaga ; Amatoury, Jason ; Kirkness, Jason P. ; Patil, Susheel. / Sleep and respiratory physiology in adults. In: Clinics in Chest Medicine. 2014 ; Vol. 35, No. 3. pp. 469-481.
@article{def05bd66fe04d7f8d932cdae86fb18c,
title = "Sleep and respiratory physiology in adults",
abstract = "Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.",
keywords = "Control of breathing, Hypoventilation, Lower airway, Respiratory physiology, Sleep effects, Upper airway",
author = "Mudiaga Sowho and Jason Amatoury and Kirkness, {Jason P.} and Susheel Patil",
year = "2014",
doi = "10.1016/j.ccm.2014.06.002",
language = "English (US)",
volume = "35",
pages = "469--481",
journal = "Clinics in Chest Medicine",
issn = "0272-5231",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Sleep and respiratory physiology in adults

AU - Sowho, Mudiaga

AU - Amatoury, Jason

AU - Kirkness, Jason P.

AU - Patil, Susheel

PY - 2014

Y1 - 2014

N2 - Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.

AB - Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.

KW - Control of breathing

KW - Hypoventilation

KW - Lower airway

KW - Respiratory physiology

KW - Sleep effects

KW - Upper airway

UR - http://www.scopus.com/inward/record.url?scp=84906790604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906790604&partnerID=8YFLogxK

U2 - 10.1016/j.ccm.2014.06.002

DO - 10.1016/j.ccm.2014.06.002

M3 - Article

C2 - 25156763

AN - SCOPUS:84906790604

VL - 35

SP - 469

EP - 481

JO - Clinics in Chest Medicine

JF - Clinics in Chest Medicine

SN - 0272-5231

IS - 3

ER -