Sleep and respiratory physiology in adults

Mudiaga Sowho; Jason Amatoury; Jason P. Kirkness; Susheel P. Patil

doi:10.1016/j.ccm.2014.06.002

Sleep and respiratory physiology in adults

Mudiaga Sowho, Jason Amatoury, Jason P. Kirkness, Susheel P. Patil

School of Medicine

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.

Original language	English (US)
Pages (from-to)	469-481
Number of pages	13
Journal	Clinics in Chest Medicine
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.ccm.2014.06.002
State	Published - Sep 2014

Keywords

Control of breathing
Hypoventilation
Lower airway
Respiratory physiology
Sleep effects
Upper airway

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.ccm.2014.06.002

Cite this

@article{def05bd66fe04d7f8d932cdae86fb18c,

title = "Sleep and respiratory physiology in adults",

abstract = "Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.",

keywords = "Control of breathing, Hypoventilation, Lower airway, Respiratory physiology, Sleep effects, Upper airway",

author = "Mudiaga Sowho and Jason Amatoury and Kirkness, {Jason P.} and Patil, {Susheel P.}",

year = "2014",

month = sep,

doi = "10.1016/j.ccm.2014.06.002",

language = "English (US)",

volume = "35",

pages = "469--481",

journal = "Clinics in Chest Medicine",

issn = "0272-5231",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Sleep and respiratory physiology in adults

AU - Sowho, Mudiaga

AU - Amatoury, Jason

AU - Kirkness, Jason P.

AU - Patil, Susheel P.

PY - 2014/9

Y1 - 2014/9

N2 - Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.

AB - Respiration during sleep is determined by metabolic demand; respiratory drive is determined by a central respiratory generator. Changes in pharyngeal dilator muscle tone resulting in increased upper airway resistance and collapsibility contribute to hypoventilation. Relative hypotonia of respiratory muscles, body posture changes, and altered ventilatory control result in additional physiologic changes contributing to hypoventilation. This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations.

KW - Control of breathing

KW - Hypoventilation

KW - Lower airway

KW - Respiratory physiology

KW - Sleep effects

KW - Upper airway

UR - http://www.scopus.com/inward/record.url?scp=84906790604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906790604&partnerID=8YFLogxK

U2 - 10.1016/j.ccm.2014.06.002

DO - 10.1016/j.ccm.2014.06.002

M3 - Review article

C2 - 25156763

AN - SCOPUS:84906790604

SN - 0272-5231

VL - 35

SP - 469

EP - 481

JO - Clinics in Chest Medicine

JF - Clinics in Chest Medicine

IS - 3

ER -

Sleep and respiratory physiology in adults

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this