Skin reactions to anti-γE antibody in atopic, nonatopic, and immunologically deficient children and adults

Richard W. Newcomb, Kimishige Ishizaka

Research output: Contribution to journalArticlepeer-review

Abstract

Guinea pig antibody to human γE (anti-γE) causes an immediate wheal and flare reaction, when small amounts are injected into human skin, considered to be mediated by antibody combining with γE on skin cells. The minimum effective dose (MED) of anti-γE causing a standard skin reaction was found to be related inversely to subjects' serum γE concentrations. Nevertheless, comparison of MED determined on atopic and nonatopic persons failed to differentiate them reliably. Patients with general defects of immunoglobulin synthesis failed to react to anti-γE except in very high doses, but patients with defects of only delayed-type reactivity reacted normally to anti-γE.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalJournal of Allergy
Volume43
Issue number5
DOIs
StatePublished - May 1969

ASJC Scopus subject areas

  • Medicine(all)

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