@article{80a763d653e24de595826480a098c325,
title = "Skin reactions to anti-γE antibody in atopic, nonatopic, and immunologically deficient children and adults",
abstract = "Guinea pig antibody to human γE (anti-γE) causes an immediate wheal and flare reaction, when small amounts are injected into human skin, considered to be mediated by antibody combining with γE on skin cells. The minimum effective dose (MED) of anti-γE causing a standard skin reaction was found to be related inversely to subjects' serum γE concentrations. Nevertheless, comparison of MED determined on atopic and nonatopic persons failed to differentiate them reliably. Patients with general defects of immunoglobulin synthesis failed to react to anti-γE except in very high doses, but patients with defects of only delayed-type reactivity reacted normally to anti-γE.",
author = "Newcomb, {Richard W.} and Kimishige Ishizaka",
note = "Funding Information: R eaginic antibody activity in sera from atopic patients has been shown to be associated with a distinct class of immunoglobulins, IgE (YE) .I Specific antibody of the yE class sensitizes human skin for the Prausnitz-Kiistner (P-K) reaction2 ; nonantibody yE blocks passive sensitization with reaginic antibody, whereas immunoglobulins of other classes fail to do ~0.~34 These findings strongly suggest that yE has an affinity for cells involved with reaginic-type allergy in human beings. In support of this, it has been found that guinea pig or rabbit antibody specific for human yE (anti-YE) causes an immediate wheal and flare when injected into normal human skin.5 The mechanism of this reversed-type reaction was considered to depend on combination of anti-YE with normal yE fixed to cells in the skin. The minimum effective dose (MED) of anti-YE required to elicit such a reaction (in the range of 10m5 pg AbN) was found to vary from person to person. Johansson6 reported that serum YE levels in adults with atopic asthma and hay fever tended to be higher, on the average, than in normal adults or in From the Children{\textquoteright}s Asthma Research Institute and Hospital. Supported by United States Public Health Service Grants AI-04985 and 5SOlFRO5523. Presented in abstract to the Section on Allergy, American Academy of Pediatrics, Chicago, Ill., Oct. 20, 1968. Received for publication Nov. 25, 1968.",
year = "1969",
month = may,
doi = "10.1016/0021-8707(69)90150-6",
language = "English (US)",
volume = "43",
pages = "292--300",
journal = "Journal of Allergy",
issn = "0021-8707",
publisher = "Mosby Inc.",
number = "5",
}