Guinea pig antibody to human γE (anti-γE) causes an immediate wheal and flare reaction, when small amounts are injected into human skin, considered to be mediated by antibody combining with γE on skin cells. The minimum effective dose (MED) of anti-γE causing a standard skin reaction was found to be related inversely to subjects' serum γE concentrations. Nevertheless, comparison of MED determined on atopic and nonatopic persons failed to differentiate them reliably. Patients with general defects of immunoglobulin synthesis failed to react to anti-γE except in very high doses, but patients with defects of only delayed-type reactivity reacted normally to anti-γE.
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