Skin biopsy-proven flecainide-induced neuropathy

Ahmet Z. Burakgazi, Michael Polydefkis, Ahmet Höke

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Flecainide acetate is a classic Ic antiarrhythmic agent used to treat a variety of cardiac arrhythmias. Non-cardiac side effects usually affect the central nervous system. Few case reports of possible flecainide-induced peripheral neuropathy have been reported. We report this unique case in that flecainide-induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalMuscle and Nerve
Issue number1
StatePublished - Jan 1 2012


  • Flecainide
  • Peripheral neuropathy
  • Potassium channel
  • Skin biopsy
  • Toxic neuropathy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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