Skin biopsy-proven flecainide-induced neuropathy

Ahmet Z. Burakgazi; Michael Polydefkis; Ahmet Höke

doi:10.1002/mus.22239

Skin biopsy-proven flecainide-induced neuropathy

Ahmet Z. Burakgazi, Michael Polydefkis, Ahmet Höke

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Flecainide acetate is a classic Ic antiarrhythmic agent used to treat a variety of cardiac arrhythmias. Non-cardiac side effects usually affect the central nervous system. Few case reports of possible flecainide-induced peripheral neuropathy have been reported. We report this unique case in that flecainide-induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy.

Original language	English (US)
Pages (from-to)	144-146
Number of pages	3
Journal	Muscle and Nerve
Volume	45
Issue number	1
DOIs	https://doi.org/10.1002/mus.22239
State	Published - Jan 1 2012

Keywords

Flecainide
Peripheral neuropathy
Potassium channel
Skin biopsy
Toxic neuropathy

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.22239

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AB - Flecainide acetate is a classic Ic antiarrhythmic agent used to treat a variety of cardiac arrhythmias. Non-cardiac side effects usually affect the central nervous system. Few case reports of possible flecainide-induced peripheral neuropathy have been reported. We report this unique case in that flecainide-induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy.

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KW - Potassium channel

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KW - Toxic neuropathy

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Skin biopsy-proven flecainide-induced neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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