Anomalies des muscles squelettiques des BPCO en insuffisance respiratoire: Apport de la spectroscopie RMN 31P

Translated title of the contribution: Skeletal muscle abnormalities in hypoxaemic COPD patients

P. Lévy, B. Wuyam, J. L. Pépin, H. Reutenauer, J. F. Payen

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


31P magnetic resonance spectroscopy ( 31P MRS) is a non-invasive method to evaluate high energy compounds [adenosine triphosphate (ATP), phosphocreatin (PCr), inorganic phosphates (Pi)] and intracellular pH (pH(i)) of skeletal muscle during exercise and recovery. It is a clinically applicable method of investigation for severe COPD patients with respiratory failure since exercise is limited to a single group of muscle (calf). Pronounced alterations of muscular metabolism have been shown in these patients: (1) reduced aerobic capacity (as reflected by the ratio of Pi/PCr as a function of power and changes in recovery kinetics of PCr after exercise and (2) increased anaerobic metabolism (reflected by a decrease in intracellular pH). Four different studies reveal similar abnormalities. Acute oxygen administration partially improves these parameters, suggesting that other factors in addition to hypoxaemia may contribute to the metabolic impairment. The effects of increased physical activity on these abnormalities deserve further investigations.

Translated title of the contributionSkeletal muscle abnormalities in hypoxaemic COPD patients
Original languageFrench
Pages (from-to)183-191
Number of pages9
JournalRevue des Maladies Respiratoires
Issue number3
StatePublished - Jun 1 1997


  • Aerobic capacity
  • COPD
  • Hypoxaemia
  • P NMR spectroscopy
  • Skeletal muscles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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