Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes

Deborah E. Sellmeyer; Roberto Civitelli; Lorenz C. Hofbauer; Sundeep Khosla; Beata Lecka-Czernik; Ann V. Schwartz

doi:10.2337/db16-0063

Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes

Deborah E. Sellmeyer, Roberto Civitelli, Lorenz C. Hofbauer, Sundeep Khosla, Beata Lecka-Czernik, Ann V. Schwartz

School of Medicine

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.

Original language	English (US)
Pages (from-to)	1757-1766
Number of pages	10
Journal	Diabetes
Volume	65
Issue number	7
DOIs	https://doi.org/10.2337/db16-0063
State	Published - Jul 1 2016

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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abstract = "Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.",

author = "Sellmeyer, {Deborah E.} and Roberto Civitelli and Hofbauer, {Lorenz C.} and Sundeep Khosla and Beata Lecka-Czernik and Schwartz, {Ann V.}",

note = "Funding Information: L.C.H. received grant support from Deutsche Forschungsgemeinschaft Sonderforschungsbereiche/Transregio 67 (Project B2). S.K. received grant support from the National Institutes of Health (AG004875 and AR027065). B.L.-C. received grant support from the American Diabetes Association (7-13-BS-089). Publisher Copyright: {\textcopyright} 2016 by the American Diabetes Association.",

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AU - Civitelli, Roberto

AU - Hofbauer, Lorenz C.

AU - Khosla, Sundeep

AU - Lecka-Czernik, Beata

AU - Schwartz, Ann V.

N1 - Funding Information: L.C.H. received grant support from Deutsche Forschungsgemeinschaft Sonderforschungsbereiche/Transregio 67 (Project B2). S.K. received grant support from the National Institutes of Health (AG004875 and AR027065). B.L.-C. received grant support from the American Diabetes Association (7-13-BS-089). Publisher Copyright: © 2016 by the American Diabetes Association.

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Y1 - 2016/7/1

N2 - Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.

AB - Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than normoglycemic individuals. Factors that increase fracture risk include lower bone mass in type 1 diabetes and compromised skeletal quality and strength despite preserved bone density in type 2 diabetes, as well as the effects of comorbidities such as diabetic macro- and microvascular complications. In this Perspective, we assess the developing scientific knowledge regarding the epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging data on the prediction, treatment, and outcomes of fractures in individuals with type 1 and type 2 diabetes.

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Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes

Abstract

ASJC Scopus subject areas

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