TY - JOUR
T1 - Sjogren syndrome
AU - Tabbara, K. F.
AU - Vera-Cristo, C. L.
PY - 2000
Y1 - 2000
N2 - Sjogren syndrome is a chronic systemic disease characterized by polyglandular tissue destruction leading to keratoconjunctivitis sicca (KCS) and xerostomia. Patients with primary Sjogren syndrome show evidence of KCS and xerostomia, whereas patients with secondary Sjogren syndrome suffer from KCS, xerostomia, and an autoimmune disease, most commonly rheumatoid arthritis. Certain factors cause autoimmune dysregulation leading to destruction of the acinar cells and ductal epithelia with subsequent dry eyes and dry mouth. Activated lymphocytes in patients with autoimmune diseases appear to have selective homing into the lacrimal and salivary glands leading to tissue damage. Understanding the factors involved in the immune dysregulation may improve our diagnostic and therapeutic approaches in Sjogren syndrome. Current therapeutic measures include means to increase secretion, relieve symptoms, and repair damage of the ocular surface. (C) 2000 Lippincott Williams and Wilkins, Inc.
AB - Sjogren syndrome is a chronic systemic disease characterized by polyglandular tissue destruction leading to keratoconjunctivitis sicca (KCS) and xerostomia. Patients with primary Sjogren syndrome show evidence of KCS and xerostomia, whereas patients with secondary Sjogren syndrome suffer from KCS, xerostomia, and an autoimmune disease, most commonly rheumatoid arthritis. Certain factors cause autoimmune dysregulation leading to destruction of the acinar cells and ductal epithelia with subsequent dry eyes and dry mouth. Activated lymphocytes in patients with autoimmune diseases appear to have selective homing into the lacrimal and salivary glands leading to tissue damage. Understanding the factors involved in the immune dysregulation may improve our diagnostic and therapeutic approaches in Sjogren syndrome. Current therapeutic measures include means to increase secretion, relieve symptoms, and repair damage of the ocular surface. (C) 2000 Lippincott Williams and Wilkins, Inc.
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U2 - 10.1097/00055735-200012000-00011
DO - 10.1097/00055735-200012000-00011
M3 - Article
C2 - 11141640
AN - SCOPUS:0033625958
SN - 1040-8738
VL - 11
SP - 449
EP - 454
JO - Current Opinion in Ophthalmology
JF - Current Opinion in Ophthalmology
IS - 6
ER -