Sizing up models of heart failure: Proteomics from flies to humans

Viola Kooij, Vidya Venkatraman, John Tra, Jonathan A. Kirk, Janelle Rowell, Anna Blice-Baum, Anthony Ross Cammarato, Jennifer E. Van Eyk

Research output: Contribution to journalArticle

Abstract

Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.

Original languageEnglish (US)
Pages (from-to)653-664
Number of pages12
JournalProteomics - Clinical Applications
Volume8
Issue number9-10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Diptera
Proteomics
Animals
Animal Models
Heart Failure
Phenotype
Amino Acid Sequence Homology
Western World
Biomarkers
Zebrafish
Proteome
Fruits
Rats
Molecular Biology
Cause of Death
Fruit
Conservation
Cardiovascular Diseases
Phosphotransferases
Swine

Keywords

  • Animal models
  • Heart failure
  • Posttranslational modifications

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Kooij, V., Venkatraman, V., Tra, J., Kirk, J. A., Rowell, J., Blice-Baum, A., ... Van Eyk, J. E. (2014). Sizing up models of heart failure: Proteomics from flies to humans. Proteomics - Clinical Applications, 8(9-10), 653-664. https://doi.org/10.1002/prca.201300123

Sizing up models of heart failure : Proteomics from flies to humans. / Kooij, Viola; Venkatraman, Vidya; Tra, John; Kirk, Jonathan A.; Rowell, Janelle; Blice-Baum, Anna; Cammarato, Anthony Ross; Van Eyk, Jennifer E.

In: Proteomics - Clinical Applications, Vol. 8, No. 9-10, 01.10.2014, p. 653-664.

Research output: Contribution to journalArticle

Kooij, V, Venkatraman, V, Tra, J, Kirk, JA, Rowell, J, Blice-Baum, A, Cammarato, AR & Van Eyk, JE 2014, 'Sizing up models of heart failure: Proteomics from flies to humans', Proteomics - Clinical Applications, vol. 8, no. 9-10, pp. 653-664. https://doi.org/10.1002/prca.201300123
Kooij V, Venkatraman V, Tra J, Kirk JA, Rowell J, Blice-Baum A et al. Sizing up models of heart failure: Proteomics from flies to humans. Proteomics - Clinical Applications. 2014 Oct 1;8(9-10):653-664. https://doi.org/10.1002/prca.201300123
Kooij, Viola ; Venkatraman, Vidya ; Tra, John ; Kirk, Jonathan A. ; Rowell, Janelle ; Blice-Baum, Anna ; Cammarato, Anthony Ross ; Van Eyk, Jennifer E. / Sizing up models of heart failure : Proteomics from flies to humans. In: Proteomics - Clinical Applications. 2014 ; Vol. 8, No. 9-10. pp. 653-664.
@article{1a0e1130175d4a83baf3973b9c66e6ef,
title = "Sizing up models of heart failure: Proteomics from flies to humans",
abstract = "Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.",
keywords = "Animal models, Heart failure, Posttranslational modifications",
author = "Viola Kooij and Vidya Venkatraman and John Tra and Kirk, {Jonathan A.} and Janelle Rowell and Anna Blice-Baum and Cammarato, {Anthony Ross} and {Van Eyk}, {Jennifer E.}",
year = "2014",
month = "10",
day = "1",
doi = "10.1002/prca.201300123",
language = "English (US)",
volume = "8",
pages = "653--664",
journal = "Proteomics - Clinical Applications",
issn = "1862-8346",
publisher = "Wiley-VCH Verlag",
number = "9-10",

}

TY - JOUR

T1 - Sizing up models of heart failure

T2 - Proteomics from flies to humans

AU - Kooij, Viola

AU - Venkatraman, Vidya

AU - Tra, John

AU - Kirk, Jonathan A.

AU - Rowell, Janelle

AU - Blice-Baum, Anna

AU - Cammarato, Anthony Ross

AU - Van Eyk, Jennifer E.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.

AB - Cardiovascular disease is the leading cause of death in the western world. Heart failure is a heterogeneous and complex syndrome, arising from various etiologies, which result in cellular phenotypes that vary from patient to patient. The ability to utilize genetic manipulation and biochemical experimentation in animal models has made them indispensable in the study of this chronic condition. Similarly, proteomics has been helpful for elucidating complicated cellular and molecular phenotypes and has the potential to identify circulating biomarkers and drug targets for therapeutic intervention. In this review, the use of human samples and animal model systems (pig, dog, rat, mouse, zebrafish, and fruit fly) in cardiac research is discussed. Additionally, the protein sequence homology between these species and the extent of conservation at the level of the phospho-proteome in major kinase signaling cascades involved in heart failure are investigated.

KW - Animal models

KW - Heart failure

KW - Posttranslational modifications

UR - http://www.scopus.com/inward/record.url?scp=84908018767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908018767&partnerID=8YFLogxK

U2 - 10.1002/prca.201300123

DO - 10.1002/prca.201300123

M3 - Article

C2 - 24723306

AN - SCOPUS:84908018767

VL - 8

SP - 653

EP - 664

JO - Proteomics - Clinical Applications

JF - Proteomics - Clinical Applications

SN - 1862-8346

IS - 9-10

ER -