TY - JOUR
T1 - Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene
AU - Oliveira, Carla R.P.
AU - Salvatori, Roberto
AU - Nóbrega, Luciana M.A.
AU - Carvalho, Erick O.M.
AU - Menezes, Menilson
AU - Farias, Catarine T.
AU - Britto, Allan V.O.
AU - Pereira, Rossana M.C.
AU - Aguiar-Oliveira, Manuel H.
PY - 2008/7
Y1 - 2008/7
N2 - Objective: To assess the sizes of intra-abdominal organs of adult subjects with untreated severe congenital isolated GH deficiency (IGHD) due to lack of functional GHRH receptor (GHRH-R), and to verify whether there is proportionality between size of organ and adult stature and body surface area (BSA). Subjects and methods: By using ultrasound, we studied the sizes (absolute and corrected by height, weight and BSA) of the intra-abdominal organs of 18 adult subjects with IGHD (eight females, IGHD group) who have never received GH replacement therapy. They were all homozygous for the same null mutation (IVS1 + 1G → A) in the GHRH receptor gene (GHRH-R). They were compared with normal controls from the same region. Results: After correction for BSA, subjects lacking a functional GHRH-R have normal prostate and ovaries size, small spleen and uterus, and large liver, pancreas and kidney. Conclusions: Size of individual abdominal organs is influenced in different ways by severe and congenital lack of GH due to a GHRH-R mutation.
AB - Objective: To assess the sizes of intra-abdominal organs of adult subjects with untreated severe congenital isolated GH deficiency (IGHD) due to lack of functional GHRH receptor (GHRH-R), and to verify whether there is proportionality between size of organ and adult stature and body surface area (BSA). Subjects and methods: By using ultrasound, we studied the sizes (absolute and corrected by height, weight and BSA) of the intra-abdominal organs of 18 adult subjects with IGHD (eight females, IGHD group) who have never received GH replacement therapy. They were all homozygous for the same null mutation (IVS1 + 1G → A) in the GHRH receptor gene (GHRH-R). They were compared with normal controls from the same region. Results: After correction for BSA, subjects lacking a functional GHRH-R have normal prostate and ovaries size, small spleen and uterus, and large liver, pancreas and kidney. Conclusions: Size of individual abdominal organs is influenced in different ways by severe and congenital lack of GH due to a GHRH-R mutation.
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U2 - 10.1111/j.1365-2265.2007.03148.x
DO - 10.1111/j.1365-2265.2007.03148.x
M3 - Article
C2 - 18034778
AN - SCOPUS:45749152148
SN - 0300-0664
VL - 69
SP - 153
EP - 158
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 1
ER -