Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene

Carla R P Oliveira, Roberto Salvatori, Luciana M A Nóbrega, Erick O M Carvalho, Menilson Menezes, Catarine T. Farias, Allan V O Britto, Rossana M C Pereira, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

Objective: To assess the sizes of intra-abdominal organs of adult subjects with untreated severe congenital isolated GH deficiency (IGHD) due to lack of functional GHRH receptor (GHRH-R), and to verify whether there is proportionality between size of organ and adult stature and body surface area (BSA). Subjects and methods: By using ultrasound, we studied the sizes (absolute and corrected by height, weight and BSA) of the intra-abdominal organs of 18 adult subjects with IGHD (eight females, IGHD group) who have never received GH replacement therapy. They were all homozygous for the same null mutation (IVS1 + 1G → A) in the GHRH receptor gene (GHRH-R). They were compared with normal controls from the same region. Results: After correction for BSA, subjects lacking a functional GHRH-R have normal prostate and ovaries size, small spleen and uterus, and large liver, pancreas and kidney. Conclusions: Size of individual abdominal organs is influenced in different ways by severe and congenital lack of GH due to a GHRH-R mutation.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalClinical Endocrinology
Volume69
Issue number1
DOIs
StatePublished - Jul 2008

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Organ Size
Pituitary Dwarfism
Body Surface Area
Mutation
Genes
Uterus
Prostate
Pancreas
Ovary
Spleen
Kidney
Weights and Measures
somatotropin releasing hormone receptor
Liver
Therapeutics

ASJC Scopus subject areas

  • Endocrinology

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Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene. / Oliveira, Carla R P; Salvatori, Roberto; Nóbrega, Luciana M A; Carvalho, Erick O M; Menezes, Menilson; Farias, Catarine T.; Britto, Allan V O; Pereira, Rossana M C; Aguiar-Oliveira, Manuel H.

In: Clinical Endocrinology, Vol. 69, No. 1, 07.2008, p. 153-158.

Research output: Contribution to journalArticle

Oliveira, Carla R P ; Salvatori, Roberto ; Nóbrega, Luciana M A ; Carvalho, Erick O M ; Menezes, Menilson ; Farias, Catarine T. ; Britto, Allan V O ; Pereira, Rossana M C ; Aguiar-Oliveira, Manuel H. / Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene. In: Clinical Endocrinology. 2008 ; Vol. 69, No. 1. pp. 153-158.
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AU - Menezes, Menilson

AU - Farias, Catarine T.

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