TY - JOUR
T1 - Sizes and distributions of intrinsic neurons incorporating tritiated GABA in monkey sensory-motor cortex
AU - Hendry, S. H.C.
AU - Jones, E. G.
PY - 1981
Y1 - 1981
N2 - Neurons accumulating [3H]γ-aminobutyric acid (GABA) were identified autoradiographically in frozen and plastic sections after injection of the material in the monkey somatic sensory (areas 3, 1, and 2), motor (area 4), and parietal (area 5) cortex following intravenous administration of a GABA transaminase inhibitor, amino-oxyacetic acid. Two general forms of labeled cells are recognized: those with large diameter (15- to 20-μm) somata, probably corresponding to the basket cells of Golgi studies, and those with small diameter (6- to 12-μm) somata, probably corresponding to several other types. The sizes and laminar distributions of labeled cells in the cytoarchitectonic fields of the first somatic sensory area (SI) are similar. In these areas, the greatest concentrations of labeled cells are in layer II, in layer IV, and in the superficial stratum of layer VI. In area 5, there are many fewer labeled cell in layer IV. In area 4, the labeled cells are larger and distributed more homogeneously, though there are fewer in layer VI. The large labeled cell type is concentrated in layers III and V of all areas. The smaller labeled types are found in all other layers, including layer I. In layer IV, they form approximately 40% of the total small-celled neuronal population.
AB - Neurons accumulating [3H]γ-aminobutyric acid (GABA) were identified autoradiographically in frozen and plastic sections after injection of the material in the monkey somatic sensory (areas 3, 1, and 2), motor (area 4), and parietal (area 5) cortex following intravenous administration of a GABA transaminase inhibitor, amino-oxyacetic acid. Two general forms of labeled cells are recognized: those with large diameter (15- to 20-μm) somata, probably corresponding to the basket cells of Golgi studies, and those with small diameter (6- to 12-μm) somata, probably corresponding to several other types. The sizes and laminar distributions of labeled cells in the cytoarchitectonic fields of the first somatic sensory area (SI) are similar. In these areas, the greatest concentrations of labeled cells are in layer II, in layer IV, and in the superficial stratum of layer VI. In area 5, there are many fewer labeled cell in layer IV. In area 4, the labeled cells are larger and distributed more homogeneously, though there are fewer in layer VI. The large labeled cell type is concentrated in layers III and V of all areas. The smaller labeled types are found in all other layers, including layer I. In layer IV, they form approximately 40% of the total small-celled neuronal population.
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U2 - 10.1523/jneurosci.01-04-00390.1981
DO - 10.1523/jneurosci.01-04-00390.1981
M3 - Article
C2 - 7264726
AN - SCOPUS:0019826818
SN - 0270-6474
VL - 1
SP - 390
EP - 408
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 4
ER -