Six-month natural history of oral versus cervical human papillomavirus infection

Gypsyamber D'Souza, Carole Fakhry, Elizabeth Sugar, Eric Carl Seaberg, Kathleen Weber, Howard L. Minkoff, Kathryn Anastos, Joel M. Palefsky, Maura L. Gillison

Research output: Contribution to journalArticle

Abstract

Human papillomavirus (HPV) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral HPV infection remains unexplored. The feasibility of studying oral HPV natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 HIV-positive and 63 HIV-negative participants. Cervical vaginal lavage samples were concurrently collected for comparison. HPV genomic DNA was detected in oral and cervical samples by consensus primer PCR and type-specified for 37 HPV types. The six-month cumulative prevalence of oral HPV infection was significantly less than for cervical infection (p <0.0001). HIV-positive women were more likely than HIV-negative women to have an oral (33 vs. 15%, p = 0.016) or cervical (78 vs. 51%, p <0.001) infection detected. Oral HPV infections detected at baseline were as likely as cervical infections to persist to 6 months among HIV-negative (60% vs. 51%, p = 0.70) and HIV-positive (55% vs. 63%, p = 0.27) women. Factors that independently elevated odds for oral HPV persistence differed from cervical infection and included current smoking (OR = 8, 95% CI = 1.3-53), age above 44 years (OR = 20, 95% CI = 4.1-83), CD4 <500 (OR = 6, 95% CI = 1.1-26), use of HAART therapy (OR = 12, 95% CI = 1.0-156), and time on HAART therapy (trend p = 0.04). The rate of oral HPV infections newly detected at follow-up was significantly lower than cervical infection among HIV-positive (p <0.001) and HIV-negative women (p <0.001). Our study not only demonstrates that it is feasible to study the natural history of oral HPV infection with oral rinse sampling, but also indicates that oral and cervical HPV natural history may differ.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalInternational Journal of Cancer
Volume121
Issue number1
DOIs
StatePublished - Jul 1 2007

Fingerprint

Papillomavirus Infections
Natural History
HIV
Highly Active Antiretroviral Therapy
Infection
Vaginal Douching
Mouth Neoplasms
HIV Infections
Smoking

Keywords

  • Cervical
  • Comparison
  • HPV
  • Human papillomavirus
  • Infection
  • Natural history
  • Oral

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Six-month natural history of oral versus cervical human papillomavirus infection. / D'Souza, Gypsyamber; Fakhry, Carole; Sugar, Elizabeth; Seaberg, Eric Carl; Weber, Kathleen; Minkoff, Howard L.; Anastos, Kathryn; Palefsky, Joel M.; Gillison, Maura L.

In: International Journal of Cancer, Vol. 121, No. 1, 01.07.2007, p. 143-150.

Research output: Contribution to journalArticle

D'Souza, Gypsyamber ; Fakhry, Carole ; Sugar, Elizabeth ; Seaberg, Eric Carl ; Weber, Kathleen ; Minkoff, Howard L. ; Anastos, Kathryn ; Palefsky, Joel M. ; Gillison, Maura L. / Six-month natural history of oral versus cervical human papillomavirus infection. In: International Journal of Cancer. 2007 ; Vol. 121, No. 1. pp. 143-150.
@article{8ca5d65dc96646ada8f3959148c0db06,
title = "Six-month natural history of oral versus cervical human papillomavirus infection",
abstract = "Human papillomavirus (HPV) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral HPV infection remains unexplored. The feasibility of studying oral HPV natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 HIV-positive and 63 HIV-negative participants. Cervical vaginal lavage samples were concurrently collected for comparison. HPV genomic DNA was detected in oral and cervical samples by consensus primer PCR and type-specified for 37 HPV types. The six-month cumulative prevalence of oral HPV infection was significantly less than for cervical infection (p <0.0001). HIV-positive women were more likely than HIV-negative women to have an oral (33 vs. 15{\%}, p = 0.016) or cervical (78 vs. 51{\%}, p <0.001) infection detected. Oral HPV infections detected at baseline were as likely as cervical infections to persist to 6 months among HIV-negative (60{\%} vs. 51{\%}, p = 0.70) and HIV-positive (55{\%} vs. 63{\%}, p = 0.27) women. Factors that independently elevated odds for oral HPV persistence differed from cervical infection and included current smoking (OR = 8, 95{\%} CI = 1.3-53), age above 44 years (OR = 20, 95{\%} CI = 4.1-83), CD4 <500 (OR = 6, 95{\%} CI = 1.1-26), use of HAART therapy (OR = 12, 95{\%} CI = 1.0-156), and time on HAART therapy (trend p = 0.04). The rate of oral HPV infections newly detected at follow-up was significantly lower than cervical infection among HIV-positive (p <0.001) and HIV-negative women (p <0.001). Our study not only demonstrates that it is feasible to study the natural history of oral HPV infection with oral rinse sampling, but also indicates that oral and cervical HPV natural history may differ.",
keywords = "Cervical, Comparison, HPV, Human papillomavirus, Infection, Natural history, Oral",
author = "Gypsyamber D'Souza and Carole Fakhry and Elizabeth Sugar and Seaberg, {Eric Carl} and Kathleen Weber and Minkoff, {Howard L.} and Kathryn Anastos and Palefsky, {Joel M.} and Gillison, {Maura L.}",
year = "2007",
month = "7",
day = "1",
doi = "10.1002/ijc.22667",
language = "English (US)",
volume = "121",
pages = "143--150",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Six-month natural history of oral versus cervical human papillomavirus infection

AU - D'Souza, Gypsyamber

AU - Fakhry, Carole

AU - Sugar, Elizabeth

AU - Seaberg, Eric Carl

AU - Weber, Kathleen

AU - Minkoff, Howard L.

AU - Anastos, Kathryn

AU - Palefsky, Joel M.

AU - Gillison, Maura L.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Human papillomavirus (HPV) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral HPV infection remains unexplored. The feasibility of studying oral HPV natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 HIV-positive and 63 HIV-negative participants. Cervical vaginal lavage samples were concurrently collected for comparison. HPV genomic DNA was detected in oral and cervical samples by consensus primer PCR and type-specified for 37 HPV types. The six-month cumulative prevalence of oral HPV infection was significantly less than for cervical infection (p <0.0001). HIV-positive women were more likely than HIV-negative women to have an oral (33 vs. 15%, p = 0.016) or cervical (78 vs. 51%, p <0.001) infection detected. Oral HPV infections detected at baseline were as likely as cervical infections to persist to 6 months among HIV-negative (60% vs. 51%, p = 0.70) and HIV-positive (55% vs. 63%, p = 0.27) women. Factors that independently elevated odds for oral HPV persistence differed from cervical infection and included current smoking (OR = 8, 95% CI = 1.3-53), age above 44 years (OR = 20, 95% CI = 4.1-83), CD4 <500 (OR = 6, 95% CI = 1.1-26), use of HAART therapy (OR = 12, 95% CI = 1.0-156), and time on HAART therapy (trend p = 0.04). The rate of oral HPV infections newly detected at follow-up was significantly lower than cervical infection among HIV-positive (p <0.001) and HIV-negative women (p <0.001). Our study not only demonstrates that it is feasible to study the natural history of oral HPV infection with oral rinse sampling, but also indicates that oral and cervical HPV natural history may differ.

AB - Human papillomavirus (HPV) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral HPV infection remains unexplored. The feasibility of studying oral HPV natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 HIV-positive and 63 HIV-negative participants. Cervical vaginal lavage samples were concurrently collected for comparison. HPV genomic DNA was detected in oral and cervical samples by consensus primer PCR and type-specified for 37 HPV types. The six-month cumulative prevalence of oral HPV infection was significantly less than for cervical infection (p <0.0001). HIV-positive women were more likely than HIV-negative women to have an oral (33 vs. 15%, p = 0.016) or cervical (78 vs. 51%, p <0.001) infection detected. Oral HPV infections detected at baseline were as likely as cervical infections to persist to 6 months among HIV-negative (60% vs. 51%, p = 0.70) and HIV-positive (55% vs. 63%, p = 0.27) women. Factors that independently elevated odds for oral HPV persistence differed from cervical infection and included current smoking (OR = 8, 95% CI = 1.3-53), age above 44 years (OR = 20, 95% CI = 4.1-83), CD4 <500 (OR = 6, 95% CI = 1.1-26), use of HAART therapy (OR = 12, 95% CI = 1.0-156), and time on HAART therapy (trend p = 0.04). The rate of oral HPV infections newly detected at follow-up was significantly lower than cervical infection among HIV-positive (p <0.001) and HIV-negative women (p <0.001). Our study not only demonstrates that it is feasible to study the natural history of oral HPV infection with oral rinse sampling, but also indicates that oral and cervical HPV natural history may differ.

KW - Cervical

KW - Comparison

KW - HPV

KW - Human papillomavirus

KW - Infection

KW - Natural history

KW - Oral

UR - http://www.scopus.com/inward/record.url?scp=34248525040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248525040&partnerID=8YFLogxK

U2 - 10.1002/ijc.22667

DO - 10.1002/ijc.22667

M3 - Article

C2 - 17354235

AN - SCOPUS:34248525040

VL - 121

SP - 143

EP - 150

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 1

ER -