Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort

Mehdi Rambod, Janos Porszasz, Barry J. Make, James D. Crapo, Richard Casaburi, Jeffrey Curtis, Ella Kazerooni, Nicola Hanania, Philip Alapat, Venkata Bandi, Kalpalatha Guntupalli, Elizabeth Guy, Antara Mallampalli, Charles Trinh, Hasan Al-Azzawi, Mustafa Atik, Dawn DeMeo, Craig Hersh, George Washko, Francine Jacobson & 108 others R. Graham Barr, Byron Thomashow, John Austin, Neil MacIntyre, Lacey Washington, H. Page McAdams, Richard Rosiello, Timothy Bresnahan, Charlene McEvoy, Joseph Tashjian, Robert A Wise, Nadia Hansel, Robert Howard Brown, Gregory B Diette, Hans Fischer, Matthew J. Budoff, Amir Sharafkhaneh, Hirani Kamal, Roham Darvishi, Dennis Niewoehner, Tadashi Allen, Quentin Anderson, Kathryn Rice, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Russell Bowler, Adam Friedlander, David Lynch, Joyce Schroeder, John Newell, Gerard Criner, Victor Kim, Nathaniel Marchetti, Aditi Satti, A. James Mamary, Robert Steiner, Chandra Dass, William Bailey, Mark Dransfield, Hrudaya Nath, Joe Ramsdell, Paul Friedman, Dwight Look, Geoffrey McLennan, Edwin J R Van Beek, Brad Thompson, Fernando Martinez, MeiLan Han, Christine Wendt, Frank Sciurba, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Antonio Anzueto, Sandra Adams, Carlos Orozco, Mario Ruiz, Edwin Silverman, Elizabeth Regan, Sarah Moyle, Lori Stepp, Rochelle Lantz, Terri L Beaty, Barbara Klanderman, Nan Laird, Christoph Lange, Michael Cho, Stephanie Santorico, John Hokanson, Jacqueline Hetmanski, Tanda Murray, John Reilly, Harvey Coxson, Philip Judy, Eric Hoffman, Raul San Jose Estepar, James Ross, Rebecca Leek, Jordan Zach, Alex Kluiber, Jered Sieren, Heather Baumhauer, Verity McArthur, Demitry Kazlouski, Deanna Richert, Tom Gethin-Jones, Andrew Allen, Tanya Mann, Anastasia Rodionova, Douglas Stinson, Robert Jensen, Homayoon Farzadegan, Stacey Meyerer, Shivam Chandan, Samantha Bragan, James Murphy, Douglas Everett, Carla Wilson, Ruthie Knowles, Amber Powell, Joe Piccoli, Maura Robinson, Margaret Forbes, Martina Wamboldt, Marci Sontag, Jennifer Black-Shinn, Gregory Kinney

Research output: Contribution to journalArticle

Abstract

Background: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV1. We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort. Methods: COPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. Phenotyping measures include postbronchodilator FEV1 % predicted and inspiratory and expiratory CT lung scans. We defined % emphysema as the percentage of lung voxels, <-950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels, <-856 Hounsfield units on the expiratory scan. Results: Data of the first 2,500 participants of the COPDGene cohort were analyzed. Participant age was 61 ± 9 years; 51% were men; 76% were non-Hispanic Caucasians, and 24% were African Americans. Fifty-six percent had spirometrically defined COPD, with 9.3%, 23.4%, 15.0%, and 8.3% in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I to IV, respectively. Higher % emphysema and % gas trapping predicted lower 6MWD (P

Original languageEnglish (US)
Pages (from-to)867-875
Number of pages9
JournalChest
Volume141
Issue number4
DOIs
StatePublished - Apr 2012

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Chronic Obstructive Pulmonary Disease
Emphysema
African Americans
Lung
Gases
Exercise Tolerance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Rambod, M., Porszasz, J., Make, B. J., Crapo, J. D., Casaburi, R., Curtis, J., ... Kinney, G. (2012). Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest, 141(4), 867-875. https://doi.org/10.1378/chest.11-0870

Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. / Rambod, Mehdi; Porszasz, Janos; Make, Barry J.; Crapo, James D.; Casaburi, Richard; Curtis, Jeffrey; Kazerooni, Ella; Hanania, Nicola; Alapat, Philip; Bandi, Venkata; Guntupalli, Kalpalatha; Guy, Elizabeth; Mallampalli, Antara; Trinh, Charles; Al-Azzawi, Hasan; Atik, Mustafa; DeMeo, Dawn; Hersh, Craig; Washko, George; Jacobson, Francine; Barr, R. Graham; Thomashow, Byron; Austin, John; MacIntyre, Neil; Washington, Lacey; McAdams, H. Page; Rosiello, Richard; Bresnahan, Timothy; McEvoy, Charlene; Tashjian, Joseph; Wise, Robert A; Hansel, Nadia; Brown, Robert Howard; Diette, Gregory B; Fischer, Hans; Budoff, Matthew J.; Sharafkhaneh, Amir; Kamal, Hirani; Darvishi, Roham; Niewoehner, Dennis; Allen, Tadashi; Anderson, Quentin; Rice, Kathryn; Foreman, Marilyn; Westney, Gloria; Berkowitz, Eugene; Bowler, Russell; Friedlander, Adam; Lynch, David; Schroeder, Joyce; Newell, John; Criner, Gerard; Kim, Victor; Marchetti, Nathaniel; Satti, Aditi; Mamary, A. James; Steiner, Robert; Dass, Chandra; Bailey, William; Dransfield, Mark; Nath, Hrudaya; Ramsdell, Joe; Friedman, Paul; Look, Dwight; McLennan, Geoffrey; Van Beek, Edwin J R; Thompson, Brad; Martinez, Fernando; Han, MeiLan; Wendt, Christine; Sciurba, Frank; Weissfeld, Joel; Fuhrman, Carl; Bon, Jessica; Anzueto, Antonio; Adams, Sandra; Orozco, Carlos; Ruiz, Mario; Silverman, Edwin; Regan, Elizabeth; Moyle, Sarah; Stepp, Lori; Lantz, Rochelle; Beaty, Terri L; Klanderman, Barbara; Laird, Nan; Lange, Christoph; Cho, Michael; Santorico, Stephanie; Hokanson, John; Hetmanski, Jacqueline; Murray, Tanda; Reilly, John; Coxson, Harvey; Judy, Philip; Hoffman, Eric; Estepar, Raul San Jose; Ross, James; Leek, Rebecca; Zach, Jordan; Kluiber, Alex; Sieren, Jered; Baumhauer, Heather; McArthur, Verity; Kazlouski, Demitry; Richert, Deanna; Gethin-Jones, Tom; Allen, Andrew; Mann, Tanya; Rodionova, Anastasia; Stinson, Douglas; Jensen, Robert; Farzadegan, Homayoon; Meyerer, Stacey; Chandan, Shivam; Bragan, Samantha; Murphy, James; Everett, Douglas; Wilson, Carla; Knowles, Ruthie; Powell, Amber; Piccoli, Joe; Robinson, Maura; Forbes, Margaret; Wamboldt, Martina; Sontag, Marci; Black-Shinn, Jennifer; Kinney, Gregory.

In: Chest, Vol. 141, No. 4, 04.2012, p. 867-875.

Research output: Contribution to journalArticle

Rambod, M, Porszasz, J, Make, BJ, Crapo, JD, Casaburi, R, Curtis, J, Kazerooni, E, Hanania, N, Alapat, P, Bandi, V, Guntupalli, K, Guy, E, Mallampalli, A, Trinh, C, Al-Azzawi, H, Atik, M, DeMeo, D, Hersh, C, Washko, G, Jacobson, F, Barr, RG, Thomashow, B, Austin, J, MacIntyre, N, Washington, L, McAdams, HP, Rosiello, R, Bresnahan, T, McEvoy, C, Tashjian, J, Wise, RA, Hansel, N, Brown, RH, Diette, GB, Fischer, H, Budoff, MJ, Sharafkhaneh, A, Kamal, H, Darvishi, R, Niewoehner, D, Allen, T, Anderson, Q, Rice, K, Foreman, M, Westney, G, Berkowitz, E, Bowler, R, Friedlander, A, Lynch, D, Schroeder, J, Newell, J, Criner, G, Kim, V, Marchetti, N, Satti, A, Mamary, AJ, Steiner, R, Dass, C, Bailey, W, Dransfield, M, Nath, H, Ramsdell, J, Friedman, P, Look, D, McLennan, G, Van Beek, EJR, Thompson, B, Martinez, F, Han, M, Wendt, C, Sciurba, F, Weissfeld, J, Fuhrman, C, Bon, J, Anzueto, A, Adams, S, Orozco, C, Ruiz, M, Silverman, E, Regan, E, Moyle, S, Stepp, L, Lantz, R, Beaty, TL, Klanderman, B, Laird, N, Lange, C, Cho, M, Santorico, S, Hokanson, J, Hetmanski, J, Murray, T, Reilly, J, Coxson, H, Judy, P, Hoffman, E, Estepar, RSJ, Ross, J, Leek, R, Zach, J, Kluiber, A, Sieren, J, Baumhauer, H, McArthur, V, Kazlouski, D, Richert, D, Gethin-Jones, T, Allen, A, Mann, T, Rodionova, A, Stinson, D, Jensen, R, Farzadegan, H, Meyerer, S, Chandan, S, Bragan, S, Murphy, J, Everett, D, Wilson, C, Knowles, R, Powell, A, Piccoli, J, Robinson, M, Forbes, M, Wamboldt, M, Sontag, M, Black-Shinn, J & Kinney, G 2012, 'Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort', Chest, vol. 141, no. 4, pp. 867-875. https://doi.org/10.1378/chest.11-0870
Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R, Curtis J et al. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr;141(4):867-875. https://doi.org/10.1378/chest.11-0870
Rambod, Mehdi ; Porszasz, Janos ; Make, Barry J. ; Crapo, James D. ; Casaburi, Richard ; Curtis, Jeffrey ; Kazerooni, Ella ; Hanania, Nicola ; Alapat, Philip ; Bandi, Venkata ; Guntupalli, Kalpalatha ; Guy, Elizabeth ; Mallampalli, Antara ; Trinh, Charles ; Al-Azzawi, Hasan ; Atik, Mustafa ; DeMeo, Dawn ; Hersh, Craig ; Washko, George ; Jacobson, Francine ; Barr, R. Graham ; Thomashow, Byron ; Austin, John ; MacIntyre, Neil ; Washington, Lacey ; McAdams, H. Page ; Rosiello, Richard ; Bresnahan, Timothy ; McEvoy, Charlene ; Tashjian, Joseph ; Wise, Robert A ; Hansel, Nadia ; Brown, Robert Howard ; Diette, Gregory B ; Fischer, Hans ; Budoff, Matthew J. ; Sharafkhaneh, Amir ; Kamal, Hirani ; Darvishi, Roham ; Niewoehner, Dennis ; Allen, Tadashi ; Anderson, Quentin ; Rice, Kathryn ; Foreman, Marilyn ; Westney, Gloria ; Berkowitz, Eugene ; Bowler, Russell ; Friedlander, Adam ; Lynch, David ; Schroeder, Joyce ; Newell, John ; Criner, Gerard ; Kim, Victor ; Marchetti, Nathaniel ; Satti, Aditi ; Mamary, A. James ; Steiner, Robert ; Dass, Chandra ; Bailey, William ; Dransfield, Mark ; Nath, Hrudaya ; Ramsdell, Joe ; Friedman, Paul ; Look, Dwight ; McLennan, Geoffrey ; Van Beek, Edwin J R ; Thompson, Brad ; Martinez, Fernando ; Han, MeiLan ; Wendt, Christine ; Sciurba, Frank ; Weissfeld, Joel ; Fuhrman, Carl ; Bon, Jessica ; Anzueto, Antonio ; Adams, Sandra ; Orozco, Carlos ; Ruiz, Mario ; Silverman, Edwin ; Regan, Elizabeth ; Moyle, Sarah ; Stepp, Lori ; Lantz, Rochelle ; Beaty, Terri L ; Klanderman, Barbara ; Laird, Nan ; Lange, Christoph ; Cho, Michael ; Santorico, Stephanie ; Hokanson, John ; Hetmanski, Jacqueline ; Murray, Tanda ; Reilly, John ; Coxson, Harvey ; Judy, Philip ; Hoffman, Eric ; Estepar, Raul San Jose ; Ross, James ; Leek, Rebecca ; Zach, Jordan ; Kluiber, Alex ; Sieren, Jered ; Baumhauer, Heather ; McArthur, Verity ; Kazlouski, Demitry ; Richert, Deanna ; Gethin-Jones, Tom ; Allen, Andrew ; Mann, Tanya ; Rodionova, Anastasia ; Stinson, Douglas ; Jensen, Robert ; Farzadegan, Homayoon ; Meyerer, Stacey ; Chandan, Shivam ; Bragan, Samantha ; Murphy, James ; Everett, Douglas ; Wilson, Carla ; Knowles, Ruthie ; Powell, Amber ; Piccoli, Joe ; Robinson, Maura ; Forbes, Margaret ; Wamboldt, Martina ; Sontag, Marci ; Black-Shinn, Jennifer ; Kinney, Gregory. / Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. In: Chest. 2012 ; Vol. 141, No. 4. pp. 867-875.
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AU - Rambod, Mehdi

AU - Porszasz, Janos

AU - Make, Barry J.

AU - Crapo, James D.

AU - Casaburi, Richard

AU - Curtis, Jeffrey

AU - Kazerooni, Ella

AU - Hanania, Nicola

AU - Alapat, Philip

AU - Bandi, Venkata

AU - Guntupalli, Kalpalatha

AU - Guy, Elizabeth

AU - Mallampalli, Antara

AU - Trinh, Charles

AU - Al-Azzawi, Hasan

AU - Atik, Mustafa

AU - DeMeo, Dawn

AU - Hersh, Craig

AU - Washko, George

AU - Jacobson, Francine

AU - Barr, R. Graham

AU - Thomashow, Byron

AU - Austin, John

AU - MacIntyre, Neil

AU - Washington, Lacey

AU - McAdams, H. Page

AU - Rosiello, Richard

AU - Bresnahan, Timothy

AU - McEvoy, Charlene

AU - Tashjian, Joseph

AU - Wise, Robert A

AU - Hansel, Nadia

AU - Brown, Robert Howard

AU - Diette, Gregory B

AU - Fischer, Hans

AU - Budoff, Matthew J.

AU - Sharafkhaneh, Amir

AU - Kamal, Hirani

AU - Darvishi, Roham

AU - Niewoehner, Dennis

AU - Allen, Tadashi

AU - Anderson, Quentin

AU - Rice, Kathryn

AU - Foreman, Marilyn

AU - Westney, Gloria

AU - Berkowitz, Eugene

AU - Bowler, Russell

AU - Friedlander, Adam

AU - Lynch, David

AU - Schroeder, Joyce

AU - Newell, John

AU - Criner, Gerard

AU - Kim, Victor

AU - Marchetti, Nathaniel

AU - Satti, Aditi

AU - Mamary, A. James

AU - Steiner, Robert

AU - Dass, Chandra

AU - Bailey, William

AU - Dransfield, Mark

AU - Nath, Hrudaya

AU - Ramsdell, Joe

AU - Friedman, Paul

AU - Look, Dwight

AU - McLennan, Geoffrey

AU - Van Beek, Edwin J R

AU - Thompson, Brad

AU - Martinez, Fernando

AU - Han, MeiLan

AU - Wendt, Christine

AU - Sciurba, Frank

AU - Weissfeld, Joel

AU - Fuhrman, Carl

AU - Bon, Jessica

AU - Anzueto, Antonio

AU - Adams, Sandra

AU - Orozco, Carlos

AU - Ruiz, Mario

AU - Silverman, Edwin

AU - Regan, Elizabeth

AU - Moyle, Sarah

AU - Stepp, Lori

AU - Lantz, Rochelle

AU - Beaty, Terri L

AU - Klanderman, Barbara

AU - Laird, Nan

AU - Lange, Christoph

AU - Cho, Michael

AU - Santorico, Stephanie

AU - Hokanson, John

AU - Hetmanski, Jacqueline

AU - Murray, Tanda

AU - Reilly, John

AU - Coxson, Harvey

AU - Judy, Philip

AU - Hoffman, Eric

AU - Estepar, Raul San Jose

AU - Ross, James

AU - Leek, Rebecca

AU - Zach, Jordan

AU - Kluiber, Alex

AU - Sieren, Jered

AU - Baumhauer, Heather

AU - McArthur, Verity

AU - Kazlouski, Demitry

AU - Richert, Deanna

AU - Gethin-Jones, Tom

AU - Allen, Andrew

AU - Mann, Tanya

AU - Rodionova, Anastasia

AU - Stinson, Douglas

AU - Jensen, Robert

AU - Farzadegan, Homayoon

AU - Meyerer, Stacey

AU - Chandan, Shivam

AU - Bragan, Samantha

AU - Murphy, James

AU - Everett, Douglas

AU - Wilson, Carla

AU - Knowles, Ruthie

AU - Powell, Amber

AU - Piccoli, Joe

AU - Robinson, Maura

AU - Forbes, Margaret

AU - Wamboldt, Martina

AU - Sontag, Marci

AU - Black-Shinn, Jennifer

AU - Kinney, Gregory

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N2 - Background: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV1. We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort. Methods: COPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. Phenotyping measures include postbronchodilator FEV1 % predicted and inspiratory and expiratory CT lung scans. We defined % emphysema as the percentage of lung voxels, <-950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels, <-856 Hounsfield units on the expiratory scan. Results: Data of the first 2,500 participants of the COPDGene cohort were analyzed. Participant age was 61 ± 9 years; 51% were men; 76% were non-Hispanic Caucasians, and 24% were African Americans. Fifty-six percent had spirometrically defined COPD, with 9.3%, 23.4%, 15.0%, and 8.3% in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I to IV, respectively. Higher % emphysema and % gas trapping predicted lower 6MWD (P

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