In two recent publications, we demonstrated that after allogeneic stimulation, regulatory T cells (Tregs) increase expression of aldehyde dehydrogenase (ALDH), the major in vivo mechanism of cyclophosphamide detoxification, thereby becoming cyclophosphamide resistant. Differential ALDH expression may explain why cyclophosphamide has pro- and anti-inflammatory effects that are temporally and contextually dependent.
- Aldehyde dehydrogenase
- Post-transplantation cyclophosphamide
- Regulatory T cell
ASJC Scopus subject areas
- Immunology and Allergy