Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent

Christopher G. Kanakry, Sudipto Ganguly, Leo Luznik

Research output: Contribution to journalArticlepeer-review

Abstract

In two recent publications, we demonstrated that after allogeneic stimulation, regulatory T cells (Tregs) increase expression of aldehyde dehydrogenase (ALDH), the major in vivo mechanism of cyclophosphamide detoxification, thereby becoming cyclophosphamide resistant. Differential ALDH expression may explain why cyclophosphamide has pro- and anti-inflammatory effects that are temporally and contextually dependent.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume4
Issue number3
DOIs
StatePublished - 2015

Keywords

  • ALDH
  • Aldehyde dehydrogenase
  • Allogeneic
  • BMT
  • Cyclophosphamide
  • Post-transplantation cyclophosphamide
  • Regulatory T cell
  • Tolerance
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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