@article{096195696bac41f2b73bcb1edc3f27d3,
title = "Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent",
abstract = "In two recent publications, we demonstrated that after allogeneic stimulation, regulatory T cells (Tregs) increase expression of aldehyde dehydrogenase (ALDH), the major in vivo mechanism of cyclophosphamide detoxification, thereby becoming cyclophosphamide resistant. Differential ALDH expression may explain why cyclophosphamide has pro- and anti-inflammatory effects that are temporally and contextually dependent.",
keywords = "ALDH, Aldehyde dehydrogenase, Allogeneic, BMT, Cyclophosphamide, Post-transplantation cyclophosphamide, Regulatory T cell, Tolerance, Treg",
author = "Kanakry, {Christopher G.} and Sudipto Ganguly and Leo Luznik",
note = "Funding Information: The work described in this article was funded by the National Institutes of Health (RO1-HL110907, RO1- CA122779, T32-HL007525) and the Conquer Cancer Foundation of the American Society of Clinical Oncology (2012 Young Investigator Award). Funding Information: The work described in this article was funded by the National Institutes of Health (RO1-HL110907, RO1- CA122779, T32-HL007525) and the Conquer Cancer Foundation of the Amer ican Society of Clinical Oncology (2012 Young Investigator Award). Publisher Copyright: {\textcopyright} 2015 Taylor & Francis Group, LLC.",
year = "2015",
doi = "10.4161/2162402X.2014.974393",
language = "English (US)",
volume = "4",
pages = "1--3",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Landes Bioscience",
number = "3",
}