Sirtuin-7 inhibits the activity of hypoxia-inducible factors

Maimon E. Hubbi, Hongxia Hu, Kshitiz, Daniele M. Gilkes, Gregg L. Semenza

Research output: Contribution to journalArticle

Abstract

Background: The HIF-1 and HIF-2 transcription factors coordinate adaptive responses to hypoxia. Results: Sirt7 decreases HIF-1 and HIF-2 protein levels independent of its deacetylase activity. Conclusion: Sirt7 inhibits the activity of the HIF-1 and HIF-2 transcription factors. Significance: This study identifies Sirt7 as a regulator of HIF-1 and HIF-2 signaling.

Original languageEnglish (US)
Pages (from-to)20768-20775
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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