Sirtuin-7 inhibits the activity of hypoxia-inducible factors

Maimon E. Hubbi; Hongxia Hu; Kshitiz; Daniele M. Gilkes; Gregg L. Semenza

doi:10.1074/jbc.M113.476903

Sirtuin-7 inhibits the activity of hypoxia-inducible factors

Maimon E. Hubbi, Hongxia Hu, Kshitiz, Daniele M. Gilkes, Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Background: The HIF-1 and HIF-2 transcription factors coordinate adaptive responses to hypoxia. Results: Sirt7 decreases HIF-1 and HIF-2 protein levels independent of its deacetylase activity. Conclusion: Sirt7 inhibits the activity of the HIF-1 and HIF-2 transcription factors. Significance: This study identifies Sirt7 as a regulator of HIF-1 and HIF-2 signaling.

Original language	English (US)
Pages (from-to)	20768-20775
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M113.476903
State	Published - Jul 19 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.476903

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abstract = "Background: The HIF-1 and HIF-2 transcription factors coordinate adaptive responses to hypoxia. Results: Sirt7 decreases HIF-1 and HIF-2 protein levels independent of its deacetylase activity. Conclusion: Sirt7 inhibits the activity of the HIF-1 and HIF-2 transcription factors. Significance: This study identifies Sirt7 as a regulator of HIF-1 and HIF-2 signaling.",

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AU - Hubbi, Maimon E.

AU - Hu, Hongxia

AU - Kshitiz,

AU - Gilkes, Daniele M.

AU - Semenza, Gregg L.

PY - 2013/7/19

Y1 - 2013/7/19

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AB - Background: The HIF-1 and HIF-2 transcription factors coordinate adaptive responses to hypoxia. Results: Sirt7 decreases HIF-1 and HIF-2 protein levels independent of its deacetylase activity. Conclusion: Sirt7 inhibits the activity of the HIF-1 and HIF-2 transcription factors. Significance: This study identifies Sirt7 as a regulator of HIF-1 and HIF-2 signaling.

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Sirtuin-7 inhibits the activity of hypoxia-inducible factors

Abstract

ASJC Scopus subject areas

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