Sirtuin 1 activator SRT2104 protects Huntington's disease mice

Mali Jiang, Jennifer Zheng, Qi Peng, Zhipeng Hou, Jiangyang Zhang, Susumu Mori, James L. Ellis, George P. Vlasuk, Harvey Fries, Vipin Suri, Wenzhen Duan

Research output: Contribution to journalArticlepeer-review

Abstract

Sirtuin 1 is a nicotinamide adenine dinucleotide-dependent protein deacetylase which regulates longevity and improves metabolism. Activation of Sirtuin 1 confers beneficial effects in models of neurodegenerative diseases. We and others have provided convincing evidence that overexpression of Sirtuin 1 plays a neuroprotective role in mouse models of Huntington's disease. In this study, we report that SRT2104, a small molecule Sirtuin 1 activator, penetrated the blood–brain barrier, attenuated brain atrophy, improved motor function, and extended survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1.

Original languageEnglish (US)
Pages (from-to)1047-1052
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume1
Issue number12
DOIs
StatePublished - Dec 2014

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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