TY - JOUR
T1 - Sinonasal undifferentiated carcinoma
T2 - Current trends in treatment
AU - Pitman, K. T.
AU - Costantino, P. D.
AU - Lassen, L. F.
PY - 1995
Y1 - 1995
N2 - Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly aggressive neoplasm of the paranasal sinuses, which has recently been characterized as a distinct pathologic entity. The prognosis for patients with SNUC is poor. Early case reports describe patients with lesions that were clinically advanced at initial presentation and surgically unresectable. Survival was reported in months after treatment with chemotherapy and radiation. As more experience was gained with treatment of SNUC, it was found that aggressive, combined surgical therapy of lesions previously considered unresectable has shown increased survival. We report a case of a 38-year-old man with SNUC originating in the posterior ethmoid, extending into the anterior cranial fossa and orbit, who was treated with preoperative hyper-fractionated radiation therapy, chemotherapy, and craniofacial resection.
AB - Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly aggressive neoplasm of the paranasal sinuses, which has recently been characterized as a distinct pathologic entity. The prognosis for patients with SNUC is poor. Early case reports describe patients with lesions that were clinically advanced at initial presentation and surgically unresectable. Survival was reported in months after treatment with chemotherapy and radiation. As more experience was gained with treatment of SNUC, it was found that aggressive, combined surgical therapy of lesions previously considered unresectable has shown increased survival. We report a case of a 38-year-old man with SNUC originating in the posterior ethmoid, extending into the anterior cranial fossa and orbit, who was treated with preoperative hyper-fractionated radiation therapy, chemotherapy, and craniofacial resection.
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U2 - 10.1055/s-2008-1058925
DO - 10.1055/s-2008-1058925
M3 - Article
C2 - 17170968
AN - SCOPUS:0028792379
VL - 5
SP - 269
EP - 272
JO - Skull Base
JF - Skull Base
SN - 2193-6331
IS - 4
ER -