Sinonasal undifferentiated carcinoma: Current trends in treatment

K. T. Pitman, P. D. Costantino, L. F. Lassen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly aggressive neoplasm of the paranasal sinuses, which has recently been characterized as a distinct pathologic entity. The prognosis for patients with SNUC is poor. Early case reports describe patients with lesions that were clinically advanced at initial presentation and surgically unresectable. Survival was reported in months after treatment with chemotherapy and radiation. As more experience was gained with treatment of SNUC, it was found that aggressive, combined surgical therapy of lesions previously considered unresectable has shown increased survival. We report a case of a 38-year-old man with SNUC originating in the posterior ethmoid, extending into the anterior cranial fossa and orbit, who was treated with preoperative hyper-fractionated radiation therapy, chemotherapy, and craniofacial resection.

Original languageEnglish (US)
Pages (from-to)269-272
Number of pages4
JournalSkull Base Surgery
Issue number4
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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