Singlet oxygen as a possible factor in human senile nuclear cataract development

J. Samuel Zigler, John D. Goosey

Research output: Contribution to journalArticle

Abstract

The effects of photodynamically generated singlet oxygen on lens crystallins were investigated. This highly reactive oxidant can produce in crystallins in vitro the oxidative modifications characteristic of proteins from aging and cataractous lens. Additionally species capable of producing singlet oxygen in the presence of near UV radiation are shown to be present in human lenses. These findings are discussed with respect to a possible role of singlet oxygen in the etiology of human senile nuclear cataracts.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalCurrent Eye Research
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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