Single-vessel coronary artery stenosis: Myocardial perfusion imaging with gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine

Bernhard L. Gerber, David A. Bluemke, Bennett B. Chin, Raymond C. Boston, Alan W. Heldman, Joao Lima, Dara Kraitchman

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate the ability of Gadomer-17 to depict perfusion defects in a closed-chest swine model of single-vessel coronary artery disease. MATERIALS AND METHODS: Twelve pigs underwent closed-chest placement of a flow reducer for 70%-90% luminal stenosis in the proximal left anterior coronary artery. Magnetic resonance (MR) perfusion imaging with Gadomer-17 and gadopentetate dimeglumine, microsphere blood flow (MBF) testing, and technetium 99m (99mTc) 2 methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) were performed during dipyridamole vasodilation. Comparisons of percentage signal intensity (SI) increase (PSIC) in remote and ischemic myocardium were made with repeated measurements analysis of variance after injection of both tracers. RESULTS: Perfusion defects and reduced PSIC in the anterior ischemic versus the inferior remote myocardium could be identified after injection of both Gadomer-17 (PSIC, 66% ± 30 [mean ± SD] vs 100% ± 32, respectively; P <.001) and gadopentetate dimeglumine (PSIC, 49% ± 31 vs 81% ± 43, respectively; P <.005). The size of perfusion defect depicted with both tracers was highly correlated with defect size at 99mTc MIBI SPECT (r = 0.69, P <.05 for Gadomer-17 and r = 0.60, P = .05 for gadopentetate dimeglumine) and with areas of reduced MBF (r = 0.70, P <.05 for Gadomer-17 and r = 0.80, P <.05 for gadopentetate dimeglumine). PSIC also correlated with MBF(r= 0.89, P <.001 for Gadomer-17 and r= 0.75, P<.001 for gadopentetate dimeglumine). Gadomer-17 allowed differentiation of ischemic from nonischemic myocardium, as demonstrated by reduced PSIC (PSIC, 48% ± 38 vs 72% ± 31, respectively; P <.001) until 20 minutes after contrast material injection. In contrast, differentiation of ischemic from nonischemic myocardium was possible only until 55 seconds after injection of gadopentetate dimeglumine (PSIC, 36% ± 24 vs 56% ± 27, respectively; P <.005) but not at any time point thereafter. CONCLUSION: With the study conditions, Gadomer-17 provided more prolonged differentiation of ischemic from remote myocardium than that with gadopentetate dimeglumine.

Original languageEnglish (US)
Pages (from-to)104-112
Number of pages9
JournalRadiology
Volume225
Issue number1
StatePublished - Oct 1 2002

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Gadolinium DTPA
Myocardial Perfusion Imaging
Coronary Stenosis
Swine
Magnetic Resonance Imaging
Myocardium
Microspheres
Injections
Perfusion
Single-Photon Emission-Computed Tomography
Thorax
Dipyridamole
gadomer 17
Magnetic Resonance Angiography
Technetium
Vasodilation
Contrast Media
Coronary Artery Disease
Coronary Vessels
Analysis of Variance

Keywords

  • Animals
  • Heart perfusion
  • Magnetic resonance (MR), contrast media
  • Magnetic resonance (MR)contrast enhancement
  • MR
  • Myocardium
  • Myocardium, blood supply
  • SPECT

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Single-vessel coronary artery stenosis : Myocardial perfusion imaging with gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine. / Gerber, Bernhard L.; Bluemke, David A.; Chin, Bennett B.; Boston, Raymond C.; Heldman, Alan W.; Lima, Joao; Kraitchman, Dara.

In: Radiology, Vol. 225, No. 1, 01.10.2002, p. 104-112.

Research output: Contribution to journalArticle

Gerber, Bernhard L. ; Bluemke, David A. ; Chin, Bennett B. ; Boston, Raymond C. ; Heldman, Alan W. ; Lima, Joao ; Kraitchman, Dara. / Single-vessel coronary artery stenosis : Myocardial perfusion imaging with gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine. In: Radiology. 2002 ; Vol. 225, No. 1. pp. 104-112.
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title = "Single-vessel coronary artery stenosis: Myocardial perfusion imaging with gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine",
abstract = "PURPOSE: To evaluate the ability of Gadomer-17 to depict perfusion defects in a closed-chest swine model of single-vessel coronary artery disease. MATERIALS AND METHODS: Twelve pigs underwent closed-chest placement of a flow reducer for 70{\%}-90{\%} luminal stenosis in the proximal left anterior coronary artery. Magnetic resonance (MR) perfusion imaging with Gadomer-17 and gadopentetate dimeglumine, microsphere blood flow (MBF) testing, and technetium 99m (99mTc) 2 methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) were performed during dipyridamole vasodilation. Comparisons of percentage signal intensity (SI) increase (PSIC) in remote and ischemic myocardium were made with repeated measurements analysis of variance after injection of both tracers. RESULTS: Perfusion defects and reduced PSIC in the anterior ischemic versus the inferior remote myocardium could be identified after injection of both Gadomer-17 (PSIC, 66{\%} ± 30 [mean ± SD] vs 100{\%} ± 32, respectively; P <.001) and gadopentetate dimeglumine (PSIC, 49{\%} ± 31 vs 81{\%} ± 43, respectively; P <.005). The size of perfusion defect depicted with both tracers was highly correlated with defect size at 99mTc MIBI SPECT (r = 0.69, P <.05 for Gadomer-17 and r = 0.60, P = .05 for gadopentetate dimeglumine) and with areas of reduced MBF (r = 0.70, P <.05 for Gadomer-17 and r = 0.80, P <.05 for gadopentetate dimeglumine). PSIC also correlated with MBF(r= 0.89, P <.001 for Gadomer-17 and r= 0.75, P<.001 for gadopentetate dimeglumine). Gadomer-17 allowed differentiation of ischemic from nonischemic myocardium, as demonstrated by reduced PSIC (PSIC, 48{\%} ± 38 vs 72{\%} ± 31, respectively; P <.001) until 20 minutes after contrast material injection. In contrast, differentiation of ischemic from nonischemic myocardium was possible only until 55 seconds after injection of gadopentetate dimeglumine (PSIC, 36{\%} ± 24 vs 56{\%} ± 27, respectively; P <.005) but not at any time point thereafter. CONCLUSION: With the study conditions, Gadomer-17 provided more prolonged differentiation of ischemic from remote myocardium than that with gadopentetate dimeglumine.",
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author = "Gerber, {Bernhard L.} and Bluemke, {David A.} and Chin, {Bennett B.} and Boston, {Raymond C.} and Heldman, {Alan W.} and Joao Lima and Dara Kraitchman",
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T1 - Single-vessel coronary artery stenosis

T2 - Myocardial perfusion imaging with gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine

AU - Gerber, Bernhard L.

AU - Bluemke, David A.

AU - Chin, Bennett B.

AU - Boston, Raymond C.

AU - Heldman, Alan W.

AU - Lima, Joao

AU - Kraitchman, Dara

PY - 2002/10/1

Y1 - 2002/10/1

N2 - PURPOSE: To evaluate the ability of Gadomer-17 to depict perfusion defects in a closed-chest swine model of single-vessel coronary artery disease. MATERIALS AND METHODS: Twelve pigs underwent closed-chest placement of a flow reducer for 70%-90% luminal stenosis in the proximal left anterior coronary artery. Magnetic resonance (MR) perfusion imaging with Gadomer-17 and gadopentetate dimeglumine, microsphere blood flow (MBF) testing, and technetium 99m (99mTc) 2 methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) were performed during dipyridamole vasodilation. Comparisons of percentage signal intensity (SI) increase (PSIC) in remote and ischemic myocardium were made with repeated measurements analysis of variance after injection of both tracers. RESULTS: Perfusion defects and reduced PSIC in the anterior ischemic versus the inferior remote myocardium could be identified after injection of both Gadomer-17 (PSIC, 66% ± 30 [mean ± SD] vs 100% ± 32, respectively; P <.001) and gadopentetate dimeglumine (PSIC, 49% ± 31 vs 81% ± 43, respectively; P <.005). The size of perfusion defect depicted with both tracers was highly correlated with defect size at 99mTc MIBI SPECT (r = 0.69, P <.05 for Gadomer-17 and r = 0.60, P = .05 for gadopentetate dimeglumine) and with areas of reduced MBF (r = 0.70, P <.05 for Gadomer-17 and r = 0.80, P <.05 for gadopentetate dimeglumine). PSIC also correlated with MBF(r= 0.89, P <.001 for Gadomer-17 and r= 0.75, P<.001 for gadopentetate dimeglumine). Gadomer-17 allowed differentiation of ischemic from nonischemic myocardium, as demonstrated by reduced PSIC (PSIC, 48% ± 38 vs 72% ± 31, respectively; P <.001) until 20 minutes after contrast material injection. In contrast, differentiation of ischemic from nonischemic myocardium was possible only until 55 seconds after injection of gadopentetate dimeglumine (PSIC, 36% ± 24 vs 56% ± 27, respectively; P <.005) but not at any time point thereafter. CONCLUSION: With the study conditions, Gadomer-17 provided more prolonged differentiation of ischemic from remote myocardium than that with gadopentetate dimeglumine.

AB - PURPOSE: To evaluate the ability of Gadomer-17 to depict perfusion defects in a closed-chest swine model of single-vessel coronary artery disease. MATERIALS AND METHODS: Twelve pigs underwent closed-chest placement of a flow reducer for 70%-90% luminal stenosis in the proximal left anterior coronary artery. Magnetic resonance (MR) perfusion imaging with Gadomer-17 and gadopentetate dimeglumine, microsphere blood flow (MBF) testing, and technetium 99m (99mTc) 2 methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) were performed during dipyridamole vasodilation. Comparisons of percentage signal intensity (SI) increase (PSIC) in remote and ischemic myocardium were made with repeated measurements analysis of variance after injection of both tracers. RESULTS: Perfusion defects and reduced PSIC in the anterior ischemic versus the inferior remote myocardium could be identified after injection of both Gadomer-17 (PSIC, 66% ± 30 [mean ± SD] vs 100% ± 32, respectively; P <.001) and gadopentetate dimeglumine (PSIC, 49% ± 31 vs 81% ± 43, respectively; P <.005). The size of perfusion defect depicted with both tracers was highly correlated with defect size at 99mTc MIBI SPECT (r = 0.69, P <.05 for Gadomer-17 and r = 0.60, P = .05 for gadopentetate dimeglumine) and with areas of reduced MBF (r = 0.70, P <.05 for Gadomer-17 and r = 0.80, P <.05 for gadopentetate dimeglumine). PSIC also correlated with MBF(r= 0.89, P <.001 for Gadomer-17 and r= 0.75, P<.001 for gadopentetate dimeglumine). Gadomer-17 allowed differentiation of ischemic from nonischemic myocardium, as demonstrated by reduced PSIC (PSIC, 48% ± 38 vs 72% ± 31, respectively; P <.001) until 20 minutes after contrast material injection. In contrast, differentiation of ischemic from nonischemic myocardium was possible only until 55 seconds after injection of gadopentetate dimeglumine (PSIC, 36% ± 24 vs 56% ± 27, respectively; P <.005) but not at any time point thereafter. CONCLUSION: With the study conditions, Gadomer-17 provided more prolonged differentiation of ischemic from remote myocardium than that with gadopentetate dimeglumine.

KW - Animals

KW - Heart perfusion

KW - Magnetic resonance (MR), contrast media

KW - Magnetic resonance (MR)contrast enhancement

KW - MR

KW - Myocardium

KW - Myocardium, blood supply

KW - SPECT

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