Single versus multi-dose vaccine vials: An economic computational model

Bruce Y. Lee, Bryan A. Norman, Tina Marie Assi, Sheng I. Chen, Rachel R. Bailey, Jayant Rajgopal, Shawn T. Brown, Ann E. Wiringa, Donald S. Burke

Research output: Contribution to journalArticle

Abstract

Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).

Original languageEnglish (US)
Pages (from-to)5292-5300
Number of pages9
JournalVaccine
Volume28
Issue number32
DOIs
StatePublished - Jul 1 2010

Keywords

  • Doses per vial
  • Economics
  • Vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Lee, B. Y., Norman, B. A., Assi, T. M., Chen, S. I., Bailey, R. R., Rajgopal, J., Brown, S. T., Wiringa, A. E., & Burke, D. S. (2010). Single versus multi-dose vaccine vials: An economic computational model. Vaccine, 28(32), 5292-5300. https://doi.org/10.1016/j.vaccine.2010.05.048