TY - JOUR
T1 - Single versus multi-dose vaccine vials
T2 - An economic computational model
AU - Lee, Bruce Y.
AU - Norman, Bryan A.
AU - Assi, Tina Marie
AU - Chen, Sheng I.
AU - Bailey, Rachel R.
AU - Rajgopal, Jayant
AU - Brown, Shawn T.
AU - Wiringa, Ann E.
AU - Burke, Donald S.
N1 - Funding Information:
This study was supported by the Vaccine Modeling Initiative (VMI), funded by the Bill and Melinda Gates Foundation and the National Institute of General Medical Sciences Models of Infectious Agent Study (MIDAS) grant 1U54GM088491-0109. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
PY - 2010/7
Y1 - 2010/7
N2 - Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).
AB - Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).
KW - Doses per vial
KW - Economics
KW - Vaccines
UR - http://www.scopus.com/inward/record.url?scp=77954953514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954953514&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.05.048
DO - 10.1016/j.vaccine.2010.05.048
M3 - Article
C2 - 20566395
AN - SCOPUS:77954953514
SN - 0264-410X
VL - 28
SP - 5292
EP - 5300
JO - Vaccine
JF - Vaccine
IS - 32
ER -