Single unit analysis of the human ventral thalamic nuclear group: Activity correlated with movement

Frederick Lenz, H. C. Kwan, J. O. Dostrovsky, R. R. Tasker, J. T. Murphy, Y. E. Lenz

Research output: Contribution to journalArticle

Abstract

During neurosurgical operations for the relief of movement disorders, single thalamic neurons (n = 107) were identified with activity which was related to verbally cued active movements (movement-related cells). The activity of each neuron was examined during different contralateral movements in order to determine the movement which was associated with the most consistent and pronounced change in firing rate (the optimal response). The optimal response was determined by analysis of histograms of neuronal activity which were constructed by using the onset of EMG activity to synchronize successive repetitions of the active movement. Movement-related cells exhibited optimal responses associated with such movements as making a fist, extension or flexion of the wrist, flexing or extending the elbow, pointing with the entire upper extremity, extending the tongue and lifting the leg. Most movement-related cells recorded in a single parasagittal plane in an individual patient had optimal responses related to movements involving the same part of the body. Movement-related cells were classified into those that were activated in response to somatosensory stimulation (combined cells, n = 20) and those which were not (voluntary cells, n = 87). Combined cells were activated in advance of EMG activity during active movement and so could be distinguished from cells responding only to sensory stimulation (sensory cells). Movement-related cells (combined and voluntary cell types) were located anterior to sensory cells and tended to show a mediolateral somatotopic organization parallel to that of sensory cells with cutaneous receptive fields. Combined cells responded to somatosensory stimulation of the same part of the body as that involved in the active movement related to the optimal response of the cell. Combined cells responding to passive movements of a joint always had their optimal response during active movement about the same joint. The activity of combined cells during parkinsonian tremor may clarify the role of sensory feedback in tremor.

Original languageEnglish (US)
Pages (from-to)1795-1821
Number of pages27
JournalBrain
Volume113
Issue number6
StatePublished - Dec 1990

Fingerprint

Ventral Thalamic Nuclei
Neurons
Sensory feedback
Unit
Cell
Cell Movement
cells
Tremor
Human Body
Human
Movement
Unit of analysis
Joints
joints (animal)
Sensory Feedback
Neuron
Movement Disorders
neurons
movement disorders
Elbow

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Lenz, F., Kwan, H. C., Dostrovsky, J. O., Tasker, R. R., Murphy, J. T., & Lenz, Y. E. (1990). Single unit analysis of the human ventral thalamic nuclear group: Activity correlated with movement. Brain, 113(6), 1795-1821.

Single unit analysis of the human ventral thalamic nuclear group : Activity correlated with movement. / Lenz, Frederick; Kwan, H. C.; Dostrovsky, J. O.; Tasker, R. R.; Murphy, J. T.; Lenz, Y. E.

In: Brain, Vol. 113, No. 6, 12.1990, p. 1795-1821.

Research output: Contribution to journalArticle

Lenz, F, Kwan, HC, Dostrovsky, JO, Tasker, RR, Murphy, JT & Lenz, YE 1990, 'Single unit analysis of the human ventral thalamic nuclear group: Activity correlated with movement', Brain, vol. 113, no. 6, pp. 1795-1821.
Lenz F, Kwan HC, Dostrovsky JO, Tasker RR, Murphy JT, Lenz YE. Single unit analysis of the human ventral thalamic nuclear group: Activity correlated with movement. Brain. 1990 Dec;113(6):1795-1821.
Lenz, Frederick ; Kwan, H. C. ; Dostrovsky, J. O. ; Tasker, R. R. ; Murphy, J. T. ; Lenz, Y. E. / Single unit analysis of the human ventral thalamic nuclear group : Activity correlated with movement. In: Brain. 1990 ; Vol. 113, No. 6. pp. 1795-1821.
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