Single unit analysis of the human ventral thalamic nuclear group: Correlation of thalamic 'tremor cells' with the 3-6 Hz component of Parkinsonian tremor

Frederick Lenz, R. R. Tasker, H. C. Kwam, S. Schnider, R. Kwong, Y. Murayama, J. O. Dostrovsky, J. T. Murphy

Research output: Contribution to journalArticle

Abstract

Although cells firing at tremor frequency, called 'tremor cells' (Guiot et al., 1962), have often been recorded in the thalamus of parkinsonian patients, the extent of correlation between these spike trains and tremor has rarely been assessed quantitatively. This paper describes spectral cross-correlation functions calculated between the activity of 'tremor cells' and electromyogram (EMG) signals recorded from several muscles in the contralateral arm. The power occurring in the spike train at tremor frequency was described in absolute terms by the spike autopower, and in relation to the average for all spectral components by the spike autopower signal-to-noise ratio (spike autopower SNR). The probability of significant cross-correlation between the thalamic spike train and EMG at tremor frequency was assessed by the coherence at tremor frequency. Autopower spectra of the activity of many of these cells exhibited a concentration of power at tremor frequency, indicated by spike autopower SNRs as high as 18. Of the EMG signals studied, signals recorded from finger flexors were most often significantly correlated with the thalamic spike train, as assessed by the coherence at tremor frequency. Significant correlation between the thalamic spike train and finger flexor EMG activity was found in 34% of cells analyzed. Tremor frequency coherence was significantly correlated with tremor frequency spike autopower (r=0.46, p

Original languageEnglish (US)
Pages (from-to)754-764
Number of pages11
JournalJournal of Neuroscience
Volume8
Issue number3
StatePublished - 1988
Externally publishedYes

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Ventral Thalamic Nuclei
Tremor
Electromyography
Fingers
Signal-To-Noise Ratio
Thalamus
Arm

ASJC Scopus subject areas

  • Neuroscience(all)

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Single unit analysis of the human ventral thalamic nuclear group : Correlation of thalamic 'tremor cells' with the 3-6 Hz component of Parkinsonian tremor. / Lenz, Frederick; Tasker, R. R.; Kwam, H. C.; Schnider, S.; Kwong, R.; Murayama, Y.; Dostrovsky, J. O.; Murphy, J. T.

In: Journal of Neuroscience, Vol. 8, No. 3, 1988, p. 754-764.

Research output: Contribution to journalArticle

Lenz, F, Tasker, RR, Kwam, HC, Schnider, S, Kwong, R, Murayama, Y, Dostrovsky, JO & Murphy, JT 1988, 'Single unit analysis of the human ventral thalamic nuclear group: Correlation of thalamic 'tremor cells' with the 3-6 Hz component of Parkinsonian tremor', Journal of Neuroscience, vol. 8, no. 3, pp. 754-764.
Lenz, Frederick ; Tasker, R. R. ; Kwam, H. C. ; Schnider, S. ; Kwong, R. ; Murayama, Y. ; Dostrovsky, J. O. ; Murphy, J. T. / Single unit analysis of the human ventral thalamic nuclear group : Correlation of thalamic 'tremor cells' with the 3-6 Hz component of Parkinsonian tremor. In: Journal of Neuroscience. 1988 ; Vol. 8, No. 3. pp. 754-764.
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