Single-Scan in Vivo Lactate Editing with Complete Lipid and Water Suppression by Selective Multiple-Quantum-Coherence Transfer (Sel-MQC) with Application to Tumors

Qiuhong He, Dikoma C. Shungu, Peter C.M. Van Zijl, Zaver M. Bhujwalla, Jerry D. Glickson

Research output: Contribution to journalArticlepeer-review

Abstract

A novel single-scan selective homonuclear multiple-quantum coherence-transfer technique, Sel-MQC, is presented that achieves lactate editing with complete lipid and water suppression. The method is suitable for studying tissues with high fat content and those subject to substantial motion. Frequency-selective excitation is employed to selectively prepare lactate into its multiple-quantum states; lipid and water are left in the single-quantum modes and eliminated by the multiple-quantum selection gradients. The efficiency of lipid suppression is monitored by a 2D Sel-MQC experiment which separates lipid and lactate along the multiple-quantum-evolution dimension. The spatial distribution of lactate can be imaged by the spectroscopic imaging version of Sel-MQC. Sel-MQC sequences were demonstrated both in phantoms and in vivo, using subcutaneously implanted murine EMT6 tumors.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalJournal of Magnetic Resonance, Series B
Volume106
Issue number3
DOIs
StatePublished - Mar 1995

ASJC Scopus subject areas

  • Engineering(all)

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