Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help

Bazarragchaa Damdinsuren, Yongqing Zhang, Ashraf Khalil, III H. Wood William H., Kevin G. Becker, Mark J. Shlomchik, Ranjan Sen

Research output: Contribution to journalArticle

Abstract

To simulate transient B cell activation that is the likely initiator of T-dependent responses, we examined the molecular and functional consequences of a single round of immunoglobulin M (IgM) signaling. This form of activation triggered early cytosolic signaling and the transcription factor NF-κB activation indistinguishably from conventional continuous IgM crosslinking but did not induce G1 progression. However, single round IgM signaling changed the expression of chemokine and chemokine receptor genes implicated in initiating T-dependent responses, as well as accentuated responsiveness to CD40 signaling. Several features of single-round IgM signaling in vitro were recapitulated in B cells after short-term exposure to antigen in vivo. We propose that transient BCR signals prime B cells to receive T cell help by increasing the probability of B-T encounter and creating a cellular environment that is hyper-responsive to CD40 signaling.

Original languageEnglish (US)
Pages (from-to)355-366
Number of pages12
JournalImmunity
Volume32
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Antigen Receptors
Immunoglobulin M
B-Lymphocytes
T-Lymphocytes
Chemokine Receptors
Chemokines
Transcription Factors
Antigens
Genes

Keywords

  • MOLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Damdinsuren, B., Zhang, Y., Khalil, A., Wood William H., III. H., Becker, K. G., Shlomchik, M. J., & Sen, R. (2010). Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help. Immunity, 32(3), 355-366. https://doi.org/10.1016/j.immuni.2010.02.013

Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help. / Damdinsuren, Bazarragchaa; Zhang, Yongqing; Khalil, Ashraf; Wood William H., III H.; Becker, Kevin G.; Shlomchik, Mark J.; Sen, Ranjan.

In: Immunity, Vol. 32, No. 3, 03.2010, p. 355-366.

Research output: Contribution to journalArticle

Damdinsuren, B, Zhang, Y, Khalil, A, Wood William H., IIIH, Becker, KG, Shlomchik, MJ & Sen, R 2010, 'Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help', Immunity, vol. 32, no. 3, pp. 355-366. https://doi.org/10.1016/j.immuni.2010.02.013
Damdinsuren B, Zhang Y, Khalil A, Wood William H. IIIH, Becker KG, Shlomchik MJ et al. Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help. Immunity. 2010 Mar;32(3):355-366. https://doi.org/10.1016/j.immuni.2010.02.013
Damdinsuren, Bazarragchaa ; Zhang, Yongqing ; Khalil, Ashraf ; Wood William H., III H. ; Becker, Kevin G. ; Shlomchik, Mark J. ; Sen, Ranjan. / Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help. In: Immunity. 2010 ; Vol. 32, No. 3. pp. 355-366.
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