Single-nucleotide polymorphisms in TrkB and risk for depression

Findings from the women's interagency HIV study

Valeriya Avdoshina, Italo Mocchetti, Chenglong Liu, Mary A. Young, Kathryn Anastos, Mardge Cohen, Howard Crystal, Celeste L. Pearce, Elizabeth Golub, Rochelle E. Tractenberg

Research output: Contribution to journalArticle

Abstract

Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume64
Issue number2
DOIs
StatePublished - Oct 1 2013

Fingerprint

Single Nucleotide Polymorphism
HIV
Depression
Brain-Derived Neurotrophic Factor
African Americans
trkB Receptor
Nerve Growth Factor Receptors
Genes
HIV-1
Alleles
Mutation

Keywords

  • Association studies
  • BDNF
  • HIV-1
  • p75NTR
  • rs1212171
  • rs2072446

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Single-nucleotide polymorphisms in TrkB and risk for depression : Findings from the women's interagency HIV study. / Avdoshina, Valeriya; Mocchetti, Italo; Liu, Chenglong; Young, Mary A.; Anastos, Kathryn; Cohen, Mardge; Crystal, Howard; Pearce, Celeste L.; Golub, Elizabeth; Tractenberg, Rochelle E.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 64, No. 2, 01.10.2013, p. 138-141.

Research output: Contribution to journalArticle

Avdoshina, V, Mocchetti, I, Liu, C, Young, MA, Anastos, K, Cohen, M, Crystal, H, Pearce, CL, Golub, E & Tractenberg, RE 2013, 'Single-nucleotide polymorphisms in TrkB and risk for depression: Findings from the women's interagency HIV study', Journal of Acquired Immune Deficiency Syndromes, vol. 64, no. 2, pp. 138-141. https://doi.org/10.1097/QAI.0b013e3182a468e9
Avdoshina, Valeriya ; Mocchetti, Italo ; Liu, Chenglong ; Young, Mary A. ; Anastos, Kathryn ; Cohen, Mardge ; Crystal, Howard ; Pearce, Celeste L. ; Golub, Elizabeth ; Tractenberg, Rochelle E. / Single-nucleotide polymorphisms in TrkB and risk for depression : Findings from the women's interagency HIV study. In: Journal of Acquired Immune Deficiency Syndromes. 2013 ; Vol. 64, No. 2. pp. 138-141.
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