Abstract
Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.
Original language | English (US) |
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Pages (from-to) | 138-141 |
Number of pages | 4 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 64 |
Issue number | 2 |
DOIs | |
State | Published - Oct 1 2013 |
Keywords
- Association studies
- BDNF
- HIV-1
- p75NTR
- rs1212171
- rs2072446
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)