Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma

A. V. Brenner, M. A. Butler, S. S. Wang, A. M. Ruder, N. Rothman, P. A. Schulte, S. J. Chanock, H. A. Fine, M. S. Linet, P. D. Inskip

Research output: Contribution to journalArticle

Abstract

A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.

Original languageEnglish (US)
Pages (from-to)2543-2547
Number of pages5
JournalCarcinogenesis
Volume28
Issue number12
DOIs
StatePublished - Dec 2007
Externally publishedYes

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Glioma
Single Nucleotide Polymorphism
Cytokines
Genes
National Institute for Occupational Safety and Health (U.S.)
National Cancer Institute (U.S.)
Immunologic Factors
Genetic Association Studies
Interleukin-4
Autoimmune Diseases
Interleukin-6
Hypersensitivity
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

Brenner, A. V., Butler, M. A., Wang, S. S., Ruder, A. M., Rothman, N., Schulte, P. A., ... Inskip, P. D. (2007). Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. Carcinogenesis, 28(12), 2543-2547. https://doi.org/10.1093/carcin/bgm210

Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. / Brenner, A. V.; Butler, M. A.; Wang, S. S.; Ruder, A. M.; Rothman, N.; Schulte, P. A.; Chanock, S. J.; Fine, H. A.; Linet, M. S.; Inskip, P. D.

In: Carcinogenesis, Vol. 28, No. 12, 12.2007, p. 2543-2547.

Research output: Contribution to journalArticle

Brenner, AV, Butler, MA, Wang, SS, Ruder, AM, Rothman, N, Schulte, PA, Chanock, SJ, Fine, HA, Linet, MS & Inskip, PD 2007, 'Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma', Carcinogenesis, vol. 28, no. 12, pp. 2543-2547. https://doi.org/10.1093/carcin/bgm210
Brenner AV, Butler MA, Wang SS, Ruder AM, Rothman N, Schulte PA et al. Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. Carcinogenesis. 2007 Dec;28(12):2543-2547. https://doi.org/10.1093/carcin/bgm210
Brenner, A. V. ; Butler, M. A. ; Wang, S. S. ; Ruder, A. M. ; Rothman, N. ; Schulte, P. A. ; Chanock, S. J. ; Fine, H. A. ; Linet, M. S. ; Inskip, P. D. / Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. In: Carcinogenesis. 2007 ; Vol. 28, No. 12. pp. 2543-2547.
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