TY - JOUR
T1 - Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland
AU - Gallicchio, Lisa
AU - Chang, Howard
AU - Christo, Dana K.
AU - Thuita, Lucy
AU - Huang, Han Yao
AU - Strickland, Paul
AU - Ruczinski, Ingo
AU - Hoffman, Sandra C.
AU - Helzlsouer, Kathy J.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/4
Y1 - 2008/4
N2 - The purpose of this study was to examine the associations between single nucleotide polymorphisms (SNPs) in genes controlling inflammatory processes and mortality. Data were analyzed from 9,933 individuals who participated in two large community-based cohort studies conducted in Washington County, Maryland, in 1974 and 1989, designated "CLUE I" and "CLUE II," respectively. DNA from blood collected in 1989 was genotyped for 47 SNPs in 23 inflammation-related genes, including interferon-γ (IFNγ), lymphotoxin-α (LTα), tumor necrosis factor-α (TNFα), C-reactive protein (CRP), peroxisome proliferator-activated receptor (PPAR), and the human endothelial nitric oxide synthase (eNOS). All participants were followed from 1989 to the date of death or to June 20, 2005. The results showed no observable patterns of association for the SNPs and the all-cause and cause-specific mortality outcomes, although statistically significant associations were observed between at least one mortality outcome and SNPs in eNOS (reference SNP (rs) 1799983), PPARG (rs4684847), CRP (rs2794521), IFNγ (rs2069705), TNFα (rs1799964), and LTα (rs2229094). Additionally, three of the four examined CRP SNPs were strongly associated with CRP serum concentration among those with CRP measurements. The authors' findings from this community-based prospective cohort study suggest that the selected SNPs are not associated with overall or cause-specific death, although CRP genotypes may be associated with systemic inflammation.
AB - The purpose of this study was to examine the associations between single nucleotide polymorphisms (SNPs) in genes controlling inflammatory processes and mortality. Data were analyzed from 9,933 individuals who participated in two large community-based cohort studies conducted in Washington County, Maryland, in 1974 and 1989, designated "CLUE I" and "CLUE II," respectively. DNA from blood collected in 1989 was genotyped for 47 SNPs in 23 inflammation-related genes, including interferon-γ (IFNγ), lymphotoxin-α (LTα), tumor necrosis factor-α (TNFα), C-reactive protein (CRP), peroxisome proliferator-activated receptor (PPAR), and the human endothelial nitric oxide synthase (eNOS). All participants were followed from 1989 to the date of death or to June 20, 2005. The results showed no observable patterns of association for the SNPs and the all-cause and cause-specific mortality outcomes, although statistically significant associations were observed between at least one mortality outcome and SNPs in eNOS (reference SNP (rs) 1799983), PPARG (rs4684847), CRP (rs2794521), IFNγ (rs2069705), TNFα (rs1799964), and LTα (rs2229094). Additionally, three of the four examined CRP SNPs were strongly associated with CRP serum concentration among those with CRP measurements. The authors' findings from this community-based prospective cohort study suggest that the selected SNPs are not associated with overall or cause-specific death, although CRP genotypes may be associated with systemic inflammation.
KW - C-reactive protein
KW - Cohort studies
KW - Inflammation
KW - Mortality
KW - Neoplasms
KW - Polymorphism, genetic
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U2 - 10.1093/aje/kwm378
DO - 10.1093/aje/kwm378
M3 - Article
C2 - 18263601
AN - SCOPUS:41349119584
VL - 167
SP - 807
EP - 813
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 7
ER -